TY - GEN
T1 - Deteriorating neural connectivity of the hippocampal episodic memory network in mTBI patients
T2 - 2017 International Joint Conference on Neural Networks, IJCNN 2017
AU - Yan, Hao
AU - Sun, Chuanzhu
AU - Wang, Xiaocui
AU - Bai, Lijun
N1 - Publisher Copyright:
© 2017 IEEE.
PY - 2017/6/30
Y1 - 2017/6/30
N2 - The current study investigated topographies and causality profiles of left hippocampus-related brain systems identified with resting state functional correlations in mild TBI as well as healthy individuals. We found a set of significantly connected brain regions (nodes) involved in the left hippocampal intrinsic network and altered causality profiles among the identified nodes. Functional connectivity analysis showed that the hippocampal network concerning episodic memory in mild TBI survivors (mTBI) became increasingly larger than that in normal controls, especially the medial frontal gyrus (MeFG), middle frontal gyrus (MFG), and temporo-parietal conjunction area. Granger causality analysis (GCA) illustrated increased bilateral causal connectivity and ipsilateral interaction in the right hemisphere, which was in contrast to intensive ipsilateral causal connection in the left hemisphere in normal controls. We postulated that the dysfunctioned hippocampus and ineffective compensation strategy resulted in a weakening episodic memory in mTBI patients.
AB - The current study investigated topographies and causality profiles of left hippocampus-related brain systems identified with resting state functional correlations in mild TBI as well as healthy individuals. We found a set of significantly connected brain regions (nodes) involved in the left hippocampal intrinsic network and altered causality profiles among the identified nodes. Functional connectivity analysis showed that the hippocampal network concerning episodic memory in mild TBI survivors (mTBI) became increasingly larger than that in normal controls, especially the medial frontal gyrus (MeFG), middle frontal gyrus (MFG), and temporo-parietal conjunction area. Granger causality analysis (GCA) illustrated increased bilateral causal connectivity and ipsilateral interaction in the right hemisphere, which was in contrast to intensive ipsilateral causal connection in the left hemisphere in normal controls. We postulated that the dysfunctioned hippocampus and ineffective compensation strategy resulted in a weakening episodic memory in mTBI patients.
KW - Episodic memory
KW - Functional connectivity
KW - Granger causality analysis
KW - Hippocampus
KW - Traumatic brain injury
UR - https://www.scopus.com/pages/publications/85031014768
U2 - 10.1109/IJCNN.2017.7966225
DO - 10.1109/IJCNN.2017.7966225
M3 - 会议稿件
AN - SCOPUS:85031014768
T3 - Proceedings of the International Joint Conference on Neural Networks
SP - 2979
EP - 2986
BT - 2017 International Joint Conference on Neural Networks, IJCNN 2017 - Proceedings
PB - Institute of Electrical and Electronics Engineers Inc.
Y2 - 14 May 2017 through 19 May 2017
ER -