Detection of carbohydrate antigen 19-9 by a diamond solution-gate field-effect transistor sensor

Bangqiang Xu; Qianwen Zhang; Xiaohui Chang; Dan Zhang; Genqiang Chen; Shi He; Yanfeng Wang; Yangmeng Feng; Hong Xing Wang

doi:10.1016/j.matlet.2022.132116

Detection of carbohydrate antigen 19-9 by a diamond solution-gate field-effect transistor sensor

Bangqiang Xu
, Qianwen Zhang
, Xiaohui Chang
, Dan Zhang
, Genqiang Chen
, Shi He
, Yanfeng Wang
, Yangmeng Feng
, Hong Xing Wang

Faculty of Electronic and Information Engineering

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Detection of carbohydrate antigen 19-9 (CA19-9) via hydrogen-terminated diamond (H-diamond) solution-gate field-effect transistor (SGFET) sensor had been carried out for the first time. Linker molecule 1-pyrenebutyric acid–N-hydroxy succinimide ester (Pyr-NHS) was fixed on the surface of H-diamond by π-π bonding. Then, anti-CA19-9 antibody was immobilized with Pyr-NHS. After specific binding of CA19-9 and antibody, transfer characteristics of H-diamond SGFET exhibited a gate voltage shift in negative direction at the same output current. The sensitivity of sensor was obtained as −50.98 mV/Log₁₀[antigen concentration]. The minimum detection concentration was 0.001 U/mL. This article illustrated a potential application of H-diamond SGFET sensor in CA19-9 detection.

Original language	English
Article number	132116
Journal	Materials Letters
Volume	318
DOIs	https://doi.org/10.1016/j.matlet.2022.132116
State	Published - 1 Jul 2022

Keywords

CA19-9
Carbon materials
Diamond
Semiconductors
Sensors
Solution-gate field-effect transistor

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10.1016/j.matlet.2022.132116

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@article{1987953095f44b2fa3679185d86421e4,

title = "Detection of carbohydrate antigen 19-9 by a diamond solution-gate field-effect transistor sensor",

abstract = "Detection of carbohydrate antigen 19-9 (CA19-9) via hydrogen-terminated diamond (H-diamond) solution-gate field-effect transistor (SGFET) sensor had been carried out for the first time. Linker molecule 1-pyrenebutyric acid–N-hydroxy succinimide ester (Pyr-NHS) was fixed on the surface of H-diamond by π-π bonding. Then, anti-CA19-9 antibody was immobilized with Pyr-NHS. After specific binding of CA19-9 and antibody, transfer characteristics of H-diamond SGFET exhibited a gate voltage shift in negative direction at the same output current. The sensitivity of sensor was obtained as −50.98 mV/Log10[antigen concentration]. The minimum detection concentration was 0.001 U/mL. This article illustrated a potential application of H-diamond SGFET sensor in CA19-9 detection.",

keywords = "CA19-9, Carbon materials, Diamond, Semiconductors, Sensors, Solution-gate field-effect transistor",

author = "Bangqiang Xu and Qianwen Zhang and Xiaohui Chang and Dan Zhang and Genqiang Chen and Shi He and Yanfeng Wang and Yangmeng Feng and Wang, \{Hong Xing\}",

note = "Publisher Copyright: {\textcopyright} 2022",

year = "2022",

month = jul,

day = "1",

doi = "10.1016/j.matlet.2022.132116",

language = "英语",

volume = "318",

journal = "Materials Letters",

issn = "0167-577X",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Detection of carbohydrate antigen 19-9 by a diamond solution-gate field-effect transistor sensor

AU - Xu, Bangqiang

AU - Zhang, Qianwen

AU - Chang, Xiaohui

AU - Zhang, Dan

AU - Chen, Genqiang

AU - He, Shi

AU - Wang, Yanfeng

AU - Feng, Yangmeng

AU - Wang, Hong Xing

PY - 2022/7/1

Y1 - 2022/7/1

N2 - Detection of carbohydrate antigen 19-9 (CA19-9) via hydrogen-terminated diamond (H-diamond) solution-gate field-effect transistor (SGFET) sensor had been carried out for the first time. Linker molecule 1-pyrenebutyric acid–N-hydroxy succinimide ester (Pyr-NHS) was fixed on the surface of H-diamond by π-π bonding. Then, anti-CA19-9 antibody was immobilized with Pyr-NHS. After specific binding of CA19-9 and antibody, transfer characteristics of H-diamond SGFET exhibited a gate voltage shift in negative direction at the same output current. The sensitivity of sensor was obtained as −50.98 mV/Log10[antigen concentration]. The minimum detection concentration was 0.001 U/mL. This article illustrated a potential application of H-diamond SGFET sensor in CA19-9 detection.

AB - Detection of carbohydrate antigen 19-9 (CA19-9) via hydrogen-terminated diamond (H-diamond) solution-gate field-effect transistor (SGFET) sensor had been carried out for the first time. Linker molecule 1-pyrenebutyric acid–N-hydroxy succinimide ester (Pyr-NHS) was fixed on the surface of H-diamond by π-π bonding. Then, anti-CA19-9 antibody was immobilized with Pyr-NHS. After specific binding of CA19-9 and antibody, transfer characteristics of H-diamond SGFET exhibited a gate voltage shift in negative direction at the same output current. The sensitivity of sensor was obtained as −50.98 mV/Log10[antigen concentration]. The minimum detection concentration was 0.001 U/mL. This article illustrated a potential application of H-diamond SGFET sensor in CA19-9 detection.

KW - CA19-9

KW - Carbon materials

KW - Diamond

KW - Semiconductors

KW - Sensors

KW - Solution-gate field-effect transistor

UR - https://www.scopus.com/pages/publications/85127343299

U2 - 10.1016/j.matlet.2022.132116

DO - 10.1016/j.matlet.2022.132116

M3 - 文章

AN - SCOPUS:85127343299

SN - 0167-577X

VL - 318

JO - Materials Letters

JF - Materials Letters

M1 - 132116

ER -

Detection of carbohydrate antigen 19-9 by a diamond solution-gate field-effect transistor sensor

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Keywords

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