Destructive Effect of DBCD Plasma on HBsAg in Human Blood and Its Impact on Erythrocyte Functions

Xing Min Shi; Jie Wen Li; Li Zhe Zhu; Si Le Chen; Xi Li Wu; Gui Min Xu; Xiao Xue Long; Jun Liang; Cong Wei Yao; Wen Long Liao; Jing Fen Cai; Shi Han Zhang; Guan Jun Zhang

doi:10.1109/TPS.2016.2593499

Destructive Effect of DBCD Plasma on HBsAg in Human Blood and Its Impact on Erythrocyte Functions

Xing Min Shi
, Jie Wen Li
, Li Zhe Zhu
, Si Le Chen
, Xi Li Wu
, Gui Min Xu
, Xiao Xue Long
, Jun Liang
, Cong Wei Yao
, Wen Long Liao
, Jing Fen Cai
, Shi Han Zhang
, Guan Jun Zhang

School of Electrical Engineering

Xi'an Jiaotong University

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

This paper aimed to investigate the destructive effect of an atmospheric-pressure low-temperature plasma (LTP) on hepatitis B surface antigen (HBsAg) in human blood as well as its impact on the functions of erythrocytes. Dielectric barrier corona discharge was used to generate the atmospheric-pressure LTP to treat the blood samples collected from hepatitis B patients with positive HBsAg, HBeAg, and anti-HBc, but negative HBsAb and HBeAb. The experimental results showed that the antigenicity of HBsAg in blood samples changed from positive to negative after being treated with the LTP for more than 40 s. Furthermore, the investigations demonstrated that after more than 30 s treatment of the LTP, osmotic fragility and malondialdehyde level of erythrocytes increased significantly, and Na⁺-K⁺-ATPase activity of erythrocytes decreased remarkably. Our results revealed that the LTP could effectively destruct HBsAg in blood and inhibit erythrocyte functions during the process.

Original language	English
Article number	7529225
Pages (from-to)	1815-1822
Number of pages	8
Journal	IEEE Transactions on Plasma Science
Volume	44
Issue number	9
DOIs	https://doi.org/10.1109/TPS.2016.2593499
State	Published - Sep 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Dielectric barrier corona discharge (DBCD)
erythrocyte functions
hepatitis B surface antigen (HbsAg)
low-temperature plasma (LTP)

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10.1109/TPS.2016.2593499

Cite this

Shi, X. M., Li, J. W., Zhu, L. Z., Chen, S. L., Wu, X. L., Xu, G. M., Long, X. X., Liang, J., Yao, C. W., Liao, W. L., Cai, J. F., Zhang, S. H., & Zhang, G. J. (2016). Destructive Effect of DBCD Plasma on HBsAg in Human Blood and Its Impact on Erythrocyte Functions. IEEE Transactions on Plasma Science, 44(9), 1815-1822. Article 7529225. https://doi.org/10.1109/TPS.2016.2593499

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title = "Destructive Effect of DBCD Plasma on HBsAg in Human Blood and Its Impact on Erythrocyte Functions",

abstract = "This paper aimed to investigate the destructive effect of an atmospheric-pressure low-temperature plasma (LTP) on hepatitis B surface antigen (HBsAg) in human blood as well as its impact on the functions of erythrocytes. Dielectric barrier corona discharge was used to generate the atmospheric-pressure LTP to treat the blood samples collected from hepatitis B patients with positive HBsAg, HBeAg, and anti-HBc, but negative HBsAb and HBeAb. The experimental results showed that the antigenicity of HBsAg in blood samples changed from positive to negative after being treated with the LTP for more than 40 s. Furthermore, the investigations demonstrated that after more than 30 s treatment of the LTP, osmotic fragility and malondialdehyde level of erythrocytes increased significantly, and Na+-K+-ATPase activity of erythrocytes decreased remarkably. Our results revealed that the LTP could effectively destruct HBsAg in blood and inhibit erythrocyte functions during the process.",

keywords = "Dielectric barrier corona discharge (DBCD), erythrocyte functions, hepatitis B surface antigen (HbsAg), low-temperature plasma (LTP)",

author = "Shi, \{Xing Min\} and Li, \{Jie Wen\} and Zhu, \{Li Zhe\} and Chen, \{Si Le\} and Wu, \{Xi Li\} and Xu, \{Gui Min\} and Long, \{Xiao Xue\} and Jun Liang and Yao, \{Cong Wei\} and Liao, \{Wen Long\} and Cai, \{Jing Fen\} and Zhang, \{Shi Han\} and Zhang, \{Guan Jun\}",

note = "Publisher Copyright: {\textcopyright} 2016 IEEE.",

year = "2016",

month = sep,

doi = "10.1109/TPS.2016.2593499",

language = "英语",

volume = "44",

pages = "1815--1822",

journal = "IEEE Transactions on Plasma Science",

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T1 - Destructive Effect of DBCD Plasma on HBsAg in Human Blood and Its Impact on Erythrocyte Functions

AU - Shi, Xing Min

AU - Li, Jie Wen

AU - Zhu, Li Zhe

AU - Chen, Si Le

AU - Wu, Xi Li

AU - Xu, Gui Min

AU - Long, Xiao Xue

AU - Liang, Jun

AU - Yao, Cong Wei

AU - Liao, Wen Long

AU - Cai, Jing Fen

AU - Zhang, Shi Han

AU - Zhang, Guan Jun

PY - 2016/9

Y1 - 2016/9

N2 - This paper aimed to investigate the destructive effect of an atmospheric-pressure low-temperature plasma (LTP) on hepatitis B surface antigen (HBsAg) in human blood as well as its impact on the functions of erythrocytes. Dielectric barrier corona discharge was used to generate the atmospheric-pressure LTP to treat the blood samples collected from hepatitis B patients with positive HBsAg, HBeAg, and anti-HBc, but negative HBsAb and HBeAb. The experimental results showed that the antigenicity of HBsAg in blood samples changed from positive to negative after being treated with the LTP for more than 40 s. Furthermore, the investigations demonstrated that after more than 30 s treatment of the LTP, osmotic fragility and malondialdehyde level of erythrocytes increased significantly, and Na+-K+-ATPase activity of erythrocytes decreased remarkably. Our results revealed that the LTP could effectively destruct HBsAg in blood and inhibit erythrocyte functions during the process.

AB - This paper aimed to investigate the destructive effect of an atmospheric-pressure low-temperature plasma (LTP) on hepatitis B surface antigen (HBsAg) in human blood as well as its impact on the functions of erythrocytes. Dielectric barrier corona discharge was used to generate the atmospheric-pressure LTP to treat the blood samples collected from hepatitis B patients with positive HBsAg, HBeAg, and anti-HBc, but negative HBsAb and HBeAb. The experimental results showed that the antigenicity of HBsAg in blood samples changed from positive to negative after being treated with the LTP for more than 40 s. Furthermore, the investigations demonstrated that after more than 30 s treatment of the LTP, osmotic fragility and malondialdehyde level of erythrocytes increased significantly, and Na+-K+-ATPase activity of erythrocytes decreased remarkably. Our results revealed that the LTP could effectively destruct HBsAg in blood and inhibit erythrocyte functions during the process.

KW - Dielectric barrier corona discharge (DBCD)

KW - erythrocyte functions

KW - hepatitis B surface antigen (HbsAg)

KW - low-temperature plasma (LTP)

UR - https://www.scopus.com/pages/publications/84981717907

U2 - 10.1109/TPS.2016.2593499

DO - 10.1109/TPS.2016.2593499

M3 - 文章

AN - SCOPUS:84981717907

SN - 0093-3813

VL - 44

SP - 1815

EP - 1822

JO - IEEE Transactions on Plasma Science

JF - IEEE Transactions on Plasma Science

IS - 9

M1 - 7529225

ER -

Destructive Effect of DBCD Plasma on HBsAg in Human Blood and Its Impact on Erythrocyte Functions

Abstract

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Keywords

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