Design and interpretation of linkage and association studies on osteoporosis

Ting Xu; Yu Cheng; Yan Guo; Lei Zhang; Yu Fang Pei; Kirk Redger; Yong Jun Liu; Hong Wen Deng

doi:10.1007/s12018-010-9070-6

Design and interpretation of linkage and association studies on osteoporosis

Ting Xu
, Yu Cheng
, Yan Guo
, Lei Zhang
, Yu Fang Pei
, Kirk Redger
, Yong Jun Liu
, Hong Wen Deng

School of Life Science and Technology (SLST)

University of Missouri at Kansas City
Central South University
Xi'an Jiaotong University
Beijing Jiaotong University

Research output: Contribution to journal › Review article › peer-review

Abstract

Osteoporosis is a common disease with strong genetic control. Genetic linkage and association studies are the two most popular methods used to investigate the genetic basis of osteoporosis. Linkage studies have been successfully used to identify quantitative trait loci (QTLs), and association studies have been widely performed to test candidate genes for osteoporosis. In this article, we review the design and interpretation of linkage and association studies on osteoporosis.

Original language	English
Pages (from-to)	60-67
Number of pages	8
Journal	Clinical Reviews in Bone and Mineral Metabolism
Volume	8
Issue number	2
DOIs	https://doi.org/10.1007/s12018-010-9070-6
State	Published - Jun 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Association
Interpretation
Linkage
Osteoporosis
Study design

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10.1007/s12018-010-9070-6

Cite this

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title = "Design and interpretation of linkage and association studies on osteoporosis",

abstract = "Osteoporosis is a common disease with strong genetic control. Genetic linkage and association studies are the two most popular methods used to investigate the genetic basis of osteoporosis. Linkage studies have been successfully used to identify quantitative trait loci (QTLs), and association studies have been widely performed to test candidate genes for osteoporosis. In this article, we review the design and interpretation of linkage and association studies on osteoporosis.",

keywords = "Association, Interpretation, Linkage, Osteoporosis, Study design",

author = "Ting Xu and Yu Cheng and Yan Guo and Lei Zhang and Pei, \{Yu Fang\} and Kirk Redger and Liu, \{Yong Jun\} and Deng, \{Hong Wen\}",

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AU - Xu, Ting

AU - Cheng, Yu

AU - Guo, Yan

AU - Zhang, Lei

AU - Pei, Yu Fang

AU - Redger, Kirk

AU - Liu, Yong Jun

AU - Deng, Hong Wen

PY - 2010/6

Y1 - 2010/6

N2 - Osteoporosis is a common disease with strong genetic control. Genetic linkage and association studies are the two most popular methods used to investigate the genetic basis of osteoporosis. Linkage studies have been successfully used to identify quantitative trait loci (QTLs), and association studies have been widely performed to test candidate genes for osteoporosis. In this article, we review the design and interpretation of linkage and association studies on osteoporosis.

AB - Osteoporosis is a common disease with strong genetic control. Genetic linkage and association studies are the two most popular methods used to investigate the genetic basis of osteoporosis. Linkage studies have been successfully used to identify quantitative trait loci (QTLs), and association studies have been widely performed to test candidate genes for osteoporosis. In this article, we review the design and interpretation of linkage and association studies on osteoporosis.

KW - Association

KW - Interpretation

KW - Linkage

KW - Osteoporosis

KW - Study design

UR - https://www.scopus.com/pages/publications/77954887372

U2 - 10.1007/s12018-010-9070-6

DO - 10.1007/s12018-010-9070-6

M3 - 文献综述

AN - SCOPUS:77954887372

SN - 1534-8644

VL - 8

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EP - 67

JO - Clinical Reviews in Bone and Mineral Metabolism

JF - Clinical Reviews in Bone and Mineral Metabolism

IS - 2

ER -

Design and interpretation of linkage and association studies on osteoporosis

Abstract

UN SDGs

Keywords

Access to Document

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