Decarboxylative Pyrazolylation of Aryl Carboxylic Acids via Synergetic Organic-Photoredox and Copper Catalysis

The decarboxylative amination of aryl carboxylic acids with low toxicity, structural diversity, and ready availability remains relatively underexplored. Current protocols typically require the use of overstoichiometric metal additives and/or strong oxidants as well as high reaction temperatures. Herein we report decarboxylative amination of aryl carboxylic acids with pyrazoles via synergistic organic-photoredox and copper catalysis under mild conditions, employing air as a green oxidant. The limitations of the current protocols are effectively addressed.