Decarboxylative Alkynylation of α-Keto Acids and Oxamic Acids in Aqueous Media

Hua Wang; Li Na Guo; Shun Wang; Xin Hua Duan

doi:10.1021/acs.orglett.5b01336

Decarboxylative Alkynylation of α-Keto Acids and Oxamic Acids in Aqueous Media

Hua Wang
, Li Na Guo
, Shun Wang
, Xin Hua Duan

School of Chemistry

Xi'an Jiaotong University

Research output: Contribution to journal › Article › peer-review

101 Scopus citations

Abstract

A mild K₂S₂O₈ promoted decarboxylative alkynylation of α-keto acids and oxamic acids has been developed. This process features mild reaction conditions, a broad substrate scope, and good functional-group tolerance, therefore providing a new and efficient access to a wide range of ynones and propiolamides. Furthermore, this radical process could also be successfully applied to alkynylation of the C_sp²-H bond in DMF with hypervalent alkynyl iodide reagents.

Original language	English
Pages (from-to)	3054-3057
Number of pages	4
Journal	Organic Letters
Volume	17
Issue number	12
DOIs	https://doi.org/10.1021/acs.orglett.5b01336
State	Published - 19 Jun 2015

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title = "Decarboxylative Alkynylation of α-Keto Acids and Oxamic Acids in Aqueous Media",

abstract = "A mild K2S2O8 promoted decarboxylative alkynylation of α-keto acids and oxamic acids has been developed. This process features mild reaction conditions, a broad substrate scope, and good functional-group tolerance, therefore providing a new and efficient access to a wide range of ynones and propiolamides. Furthermore, this radical process could also be successfully applied to alkynylation of the Csp2-H bond in DMF with hypervalent alkynyl iodide reagents.",

author = "Hua Wang and Guo, \{Li Na\} and Shun Wang and Duan, \{Xin Hua\}",

note = "Publisher Copyright: {\textcopyright} 2015 American Chemical Society.",

year = "2015",

month = jun,

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doi = "10.1021/acs.orglett.5b01336",

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T1 - Decarboxylative Alkynylation of α-Keto Acids and Oxamic Acids in Aqueous Media

AU - Wang, Hua

AU - Guo, Li Na

AU - Wang, Shun

AU - Duan, Xin Hua

PY - 2015/6/19

Y1 - 2015/6/19

N2 - A mild K2S2O8 promoted decarboxylative alkynylation of α-keto acids and oxamic acids has been developed. This process features mild reaction conditions, a broad substrate scope, and good functional-group tolerance, therefore providing a new and efficient access to a wide range of ynones and propiolamides. Furthermore, this radical process could also be successfully applied to alkynylation of the Csp2-H bond in DMF with hypervalent alkynyl iodide reagents.

AB - A mild K2S2O8 promoted decarboxylative alkynylation of α-keto acids and oxamic acids has been developed. This process features mild reaction conditions, a broad substrate scope, and good functional-group tolerance, therefore providing a new and efficient access to a wide range of ynones and propiolamides. Furthermore, this radical process could also be successfully applied to alkynylation of the Csp2-H bond in DMF with hypervalent alkynyl iodide reagents.

UR - https://www.scopus.com/pages/publications/84934943106

U2 - 10.1021/acs.orglett.5b01336

DO - 10.1021/acs.orglett.5b01336

M3 - 文章

AN - SCOPUS:84934943106

SN - 1523-7060

VL - 17

SP - 3054

EP - 3057

JO - Organic Letters

JF - Organic Letters

IS - 12

ER -

Decarboxylative Alkynylation of α-Keto Acids and Oxamic Acids in Aqueous Media

Abstract

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