D-A type (dfppy)2Ir(pic-TPA) complex containing fluorinated pyridine-2-carboxylate ligand and triphenylamine: synthesis, photophysics and bioactivity

Dan Bai; Kai Chen; Haitao Shi; Xiao Peng; Xiaoxiao Zhang; Xuyang Zheng; Hongtao Ren; Junle Qu

doi:10.1002/aoc.5320

D-A type (dfppy)₂Ir(pic-TPA) complex containing fluorinated pyridine-2-carboxylate ligand and triphenylamine: synthesis, photophysics and bioactivity

Dan Bai
, Kai Chen
, Haitao Shi
, Xiao Peng
, Xiaoxiao Zhang
, Xuyang Zheng
, Hongtao Ren
, Junle Qu

School of Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A novel Ir (III) complex (dfppy)₂Ir(pic-TPA) containing fluorinated phenylpyridine and pyridine-2-carboxylate ancillary ligand was synthesized according to rational design, its photophysical properties and therapeutical activities examined. Radiosensitization SER values (1.63-1.65) were observed even in radio-resistant cell lines after treatment with this complex. Furthermore, the complexes have shown antiviral activity against HSV-2 DNA virus. Comply with sub-cellular distribution imaging results and molecular docking calculations and cell cytometry analysis, this Ir (III) complex demonstrated functions as promising microviscosiy and micropolarity imaging probe, also as a prodrug for combinatorial therapy of radiochemo and antiviral treatment.

Original language	English
Article number	e5320
Journal	Applied Organometallic Chemistry
Volume	34
Issue number	2
DOIs	https://doi.org/10.1002/aoc.5320
State	Published - 1 Feb 2020

Keywords

antiviral
donor-acceptor pair
iridium complex
molecular rotor
radiosensitizer

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10.1002/aoc.5320

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title = "D-A type (dfppy)2Ir(pic-TPA) complex containing fluorinated pyridine-2-carboxylate ligand and triphenylamine: synthesis, photophysics and bioactivity",

abstract = "A novel Ir (III) complex (dfppy)2Ir(pic-TPA) containing fluorinated phenylpyridine and pyridine-2-carboxylate ancillary ligand was synthesized according to rational design, its photophysical properties and therapeutical activities examined. Radiosensitization SER values (1.63-1.65) were observed even in radio-resistant cell lines after treatment with this complex. Furthermore, the complexes have shown antiviral activity against HSV-2 DNA virus. Comply with sub-cellular distribution imaging results and molecular docking calculations and cell cytometry analysis, this Ir (III) complex demonstrated functions as promising microviscosiy and micropolarity imaging probe, also as a prodrug for combinatorial therapy of radiochemo and antiviral treatment.",

keywords = "antiviral, donor-acceptor pair, iridium complex, molecular rotor, radiosensitizer",

author = "Dan Bai and Kai Chen and Haitao Shi and Xiao Peng and Xiaoxiao Zhang and Xuyang Zheng and Hongtao Ren and Junle Qu",

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T1 - D-A type (dfppy)2Ir(pic-TPA) complex containing fluorinated pyridine-2-carboxylate ligand and triphenylamine

T2 - synthesis, photophysics and bioactivity

AU - Bai, Dan

AU - Chen, Kai

AU - Shi, Haitao

AU - Peng, Xiao

AU - Zhang, Xiaoxiao

AU - Zheng, Xuyang

AU - Ren, Hongtao

AU - Qu, Junle

PY - 2020/2/1

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N2 - A novel Ir (III) complex (dfppy)2Ir(pic-TPA) containing fluorinated phenylpyridine and pyridine-2-carboxylate ancillary ligand was synthesized according to rational design, its photophysical properties and therapeutical activities examined. Radiosensitization SER values (1.63-1.65) were observed even in radio-resistant cell lines after treatment with this complex. Furthermore, the complexes have shown antiviral activity against HSV-2 DNA virus. Comply with sub-cellular distribution imaging results and molecular docking calculations and cell cytometry analysis, this Ir (III) complex demonstrated functions as promising microviscosiy and micropolarity imaging probe, also as a prodrug for combinatorial therapy of radiochemo and antiviral treatment.

AB - A novel Ir (III) complex (dfppy)2Ir(pic-TPA) containing fluorinated phenylpyridine and pyridine-2-carboxylate ancillary ligand was synthesized according to rational design, its photophysical properties and therapeutical activities examined. Radiosensitization SER values (1.63-1.65) were observed even in radio-resistant cell lines after treatment with this complex. Furthermore, the complexes have shown antiviral activity against HSV-2 DNA virus. Comply with sub-cellular distribution imaging results and molecular docking calculations and cell cytometry analysis, this Ir (III) complex demonstrated functions as promising microviscosiy and micropolarity imaging probe, also as a prodrug for combinatorial therapy of radiochemo and antiviral treatment.

KW - antiviral

KW - donor-acceptor pair

KW - iridium complex

KW - molecular rotor

KW - radiosensitizer

UR - https://www.scopus.com/pages/publications/85076918142

U2 - 10.1002/aoc.5320

DO - 10.1002/aoc.5320

M3 - 文章

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SN - 0268-2605

VL - 34

JO - Applied Organometallic Chemistry

JF - Applied Organometallic Chemistry

IS - 2

M1 - e5320

ER -

D-A type (dfppy)₂Ir(pic-TPA) complex containing fluorinated pyridine-2-carboxylate ligand and triphenylamine: synthesis, photophysics and bioactivity

Abstract

Keywords

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