Cyclic poly(β-amino ester)s with enhanced gene transfection activity synthesized through intra-molecular cyclization

  • Chenfei Wang
  • , Xiaobei Huang
  • , Litao Sun
  • , Qiuxia Li
  • , Zhili Li
  • , Haiyang Yong
  • , Delu Che
  • , Cong Yan
  • , Songmei Geng
  • , Wenxin Wang
  • , Dezhong Zhou

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Topological structure plays a critical role in gene delivery of cationic polymers. Cyclic poly(β-amino ester)s (CPAEs) are successfully synthesized via sequential Michael addition and free radical initiating ring-closure reaction. The CPAEs exhibit superior gene transfection efficiency and safety profile compared to their linear counterparts.

Original languageEnglish
Pages (from-to)2136-2139
Number of pages4
JournalChemical Communications
Volume58
Issue number13
DOIs
StatePublished - 14 Feb 2022

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