TY - JOUR
T1 - Current and future opportunities for lateral flow immunoassay strips based on tunable plasmonic properties of gold nanoparticles
AU - Fu, Yu Fang
AU - Zhu, Jian
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature 2025.
PY - 2025/8
Y1 - 2025/8
N2 - Gold nanoparticles (AuNPs) are widely used in biomedical sensing due to their tunable localized surface plasmon resonance (LSPR) optical properties. The need for traditional sensing methods that do not offer the advantages of timeliness and portability has been addressed by the introduction of lateral flow immunoassay (LFIA) strips, a point-of-care testing (POCT) tool, which offers the advantages of simplicity of handling, visualization, and short detection times. Thus, the combination between LSPR of AuNPs and LFIA strips has evolved to provide a powerful platform capable of ultrasensitive and multiplexed detection of a wide range of target analytes. In recent years, many new types of AuNPs with special morphologic structure and excellent plasmonic optical properties have been developed and used in LFIA. This review focuses on recent advances in novel morphologies and modifications of AuNPs as probes for LFIA strips, highlighting their applications in POCT detection through colorimetric, surface-enhanced Raman scattering, fluorescent, photothermal, and multimodal approaches.
AB - Gold nanoparticles (AuNPs) are widely used in biomedical sensing due to their tunable localized surface plasmon resonance (LSPR) optical properties. The need for traditional sensing methods that do not offer the advantages of timeliness and portability has been addressed by the introduction of lateral flow immunoassay (LFIA) strips, a point-of-care testing (POCT) tool, which offers the advantages of simplicity of handling, visualization, and short detection times. Thus, the combination between LSPR of AuNPs and LFIA strips has evolved to provide a powerful platform capable of ultrasensitive and multiplexed detection of a wide range of target analytes. In recent years, many new types of AuNPs with special morphologic structure and excellent plasmonic optical properties have been developed and used in LFIA. This review focuses on recent advances in novel morphologies and modifications of AuNPs as probes for LFIA strips, highlighting their applications in POCT detection through colorimetric, surface-enhanced Raman scattering, fluorescent, photothermal, and multimodal approaches.
KW - Colorimetric detection
KW - Fluorescence detection
KW - Gold nanoparticles
KW - Lateral flow immunoassay strips
KW - Photothermal detection
KW - Surface-enhanced Raman scattering
UR - https://www.scopus.com/pages/publications/105010554760
U2 - 10.1007/s00604-025-07352-1
DO - 10.1007/s00604-025-07352-1
M3 - 文献综述
C2 - 40650679
AN - SCOPUS:105010554760
SN - 0026-3672
VL - 192
JO - Microchimica Acta
JF - Microchimica Acta
IS - 8
M1 - 501
ER -