TY - JOUR
T1 - Curcumin inhibits Cancer-associated fibroblast-driven prostate cancer invasion through MAOA/mTOR/HIF-1α signaling
AU - Du, Yuefeng
AU - Long, Qingzhi
AU - Zhang, Lin
AU - Shi, Ying
AU - Liu, Xioagang
AU - Li, Xudong
AU - Guan, Bin
AU - Tian, Yanchao
AU - Wang, Xinyang
AU - Li, Lei
AU - He, Dalin
PY - 2015/12
Y1 - 2015/12
N2 - Cancer-associated fibroblasts (CAFs) are key determinants in the malignant progression of cancer, supporting tumorigenesis and metastasis. CAFs also mediate epithelial to mesenchymal transition (EMT) in tumor cells and their achievement of stem cell traits. Curcumin has recently been found to possess anticancer activities via its effect on a variety of biological pathways involved in cancer progression. In this study, we found that CAFs could induce prostate cancer cell EMT and invasion through a monoamine oxidase A (MAOA)/mammalian target of rapamycin (mTOR)/hypoxia-inducible factor-1α (HIF-1α) signaling pathway, which exploits reactive oxygen species (ROS) to drive a migratory and aggressive phenotype of prostate carcinoma cells. Moreover, CAFs was able to increase CXC chemokine receptor 4 (CXCR4) and interleukin-6 (IL-6) receptor expression in prostate cancer cells. However, curcumin abrogated CAF-induced invasion and EMT, and inhibited ROS production and CXCR4 and IL-6 receptor expression in prostate cancer cells through inhibiting MAOA/mTOR/HIF-1α signaling, thereby supporting the therapeutic effect of curcumin in prostate cancer.
AB - Cancer-associated fibroblasts (CAFs) are key determinants in the malignant progression of cancer, supporting tumorigenesis and metastasis. CAFs also mediate epithelial to mesenchymal transition (EMT) in tumor cells and their achievement of stem cell traits. Curcumin has recently been found to possess anticancer activities via its effect on a variety of biological pathways involved in cancer progression. In this study, we found that CAFs could induce prostate cancer cell EMT and invasion through a monoamine oxidase A (MAOA)/mammalian target of rapamycin (mTOR)/hypoxia-inducible factor-1α (HIF-1α) signaling pathway, which exploits reactive oxygen species (ROS) to drive a migratory and aggressive phenotype of prostate carcinoma cells. Moreover, CAFs was able to increase CXC chemokine receptor 4 (CXCR4) and interleukin-6 (IL-6) receptor expression in prostate cancer cells. However, curcumin abrogated CAF-induced invasion and EMT, and inhibited ROS production and CXCR4 and IL-6 receptor expression in prostate cancer cells through inhibiting MAOA/mTOR/HIF-1α signaling, thereby supporting the therapeutic effect of curcumin in prostate cancer.
KW - Cancer-associated fibroblasts
KW - Curcumin
KW - Invasion
KW - Monoamine oxidase A/mammalian target of rapamycin/hypoxia-inducible factor-1α signaling
KW - Prostate cancer
UR - https://www.scopus.com/pages/publications/84982732251
U2 - 10.3892/ijo.2015.3202
DO - 10.3892/ijo.2015.3202
M3 - 文章
C2 - 26499200
AN - SCOPUS:84982732251
SN - 1019-6439
VL - 47
SP - 2064
EP - 2072
JO - International Journal of Oncology
JF - International Journal of Oncology
IS - 6
ER -
