Coregulatory long non-coding RNA and protein-coding genes in serum starved cells

Fan Wang; Rui Liang; Benjamin Soibam; Jin Yang; Yu Liu

doi:10.1016/j.bbagrm.2018.11.004

Coregulatory long non-coding RNA and protein-coding genes in serum starved cells

Fan Wang
, Rui Liang
, Benjamin Soibam
, Jin Yang
, Yu Liu

The First Affiliated Hospital of Xi’an Jiaotong University
University of Houston
University of Houston-Downtown

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Serum starvation is widely used in cell biology to trigger cell cycle arrest, apoptosis, autophagy, and metabolic adaptations. Serum starvation-related molecular events have been well characterized at protein level but not at transcript level: how long non-coding RNAs contribute to the regulation of protein-coding genes is largely unknown. Here, we captured the lncRNA transcriptome in serum starved mouse embryonic fibroblasts and identified three main modes of action: cis-acting/coregulatory, trans-acting, and “miRNA-carrier”. Whole-genome and individual gene level analyses support that our annotation provides an important platform for understanding lncRNA/protein-coding gene coregulatory mechanisms in serum starvation.

Original language	English
Pages (from-to)	84-95
Number of pages	12
Journal	Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
Volume	1862
Issue number	1
DOIs	https://doi.org/10.1016/j.bbagrm.2018.11.004
State	Published - Jan 2019
Externally published	Yes

Keywords

Autophagy
H19X
Lockd
Miat
lncRNA

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10.1016/j.bbagrm.2018.11.004

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title = "Coregulatory long non-coding RNA and protein-coding genes in serum starved cells",

abstract = "Serum starvation is widely used in cell biology to trigger cell cycle arrest, apoptosis, autophagy, and metabolic adaptations. Serum starvation-related molecular events have been well characterized at protein level but not at transcript level: how long non-coding RNAs contribute to the regulation of protein-coding genes is largely unknown. Here, we captured the lncRNA transcriptome in serum starved mouse embryonic fibroblasts and identified three main modes of action: cis-acting/coregulatory, trans-acting, and “miRNA-carrier”. Whole-genome and individual gene level analyses support that our annotation provides an important platform for understanding lncRNA/protein-coding gene coregulatory mechanisms in serum starvation.",

keywords = "Autophagy, H19X, Lockd, Miat, lncRNA",

author = "Fan Wang and Rui Liang and Benjamin Soibam and Jin Yang and Yu Liu",

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year = "2019",

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doi = "10.1016/j.bbagrm.2018.11.004",

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AU - Wang, Fan

AU - Liang, Rui

AU - Soibam, Benjamin

AU - Yang, Jin

AU - Liu, Yu

PY - 2019/1

Y1 - 2019/1

N2 - Serum starvation is widely used in cell biology to trigger cell cycle arrest, apoptosis, autophagy, and metabolic adaptations. Serum starvation-related molecular events have been well characterized at protein level but not at transcript level: how long non-coding RNAs contribute to the regulation of protein-coding genes is largely unknown. Here, we captured the lncRNA transcriptome in serum starved mouse embryonic fibroblasts and identified three main modes of action: cis-acting/coregulatory, trans-acting, and “miRNA-carrier”. Whole-genome and individual gene level analyses support that our annotation provides an important platform for understanding lncRNA/protein-coding gene coregulatory mechanisms in serum starvation.

AB - Serum starvation is widely used in cell biology to trigger cell cycle arrest, apoptosis, autophagy, and metabolic adaptations. Serum starvation-related molecular events have been well characterized at protein level but not at transcript level: how long non-coding RNAs contribute to the regulation of protein-coding genes is largely unknown. Here, we captured the lncRNA transcriptome in serum starved mouse embryonic fibroblasts and identified three main modes of action: cis-acting/coregulatory, trans-acting, and “miRNA-carrier”. Whole-genome and individual gene level analyses support that our annotation provides an important platform for understanding lncRNA/protein-coding gene coregulatory mechanisms in serum starvation.

KW - Autophagy

KW - H19X

KW - Lockd

KW - Miat

KW - lncRNA

UR - https://www.scopus.com/pages/publications/85057857946

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DO - 10.1016/j.bbagrm.2018.11.004

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AN - SCOPUS:85057857946

SN - 1874-9399

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JO - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

JF - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

IS - 1

ER -

Coregulatory long non-coding RNA and protein-coding genes in serum starved cells

Abstract

Keywords

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