Copper-mediated trifluoromethylation of propiolic acids: Facile synthesis of α-trifluoromethyl ketones

Zhengbiao He; Rui Zhang; Mingyou Hu; Lingchun Li; Chuanfa Ni; Jinbo Hu

doi:10.1039/c3sc51613j

Copper-mediated trifluoromethylation of propiolic acids: Facile synthesis of α-trifluoromethyl ketones

Zhengbiao He
, Rui Zhang
, Mingyou Hu
, Lingchun Li
, Chuanfa Ni
, Jinbo Hu

CAS - Shanghai Institute of Organic Chemistry

Research output: Contribution to journal › Article › peer-review

99 Scopus citations

Abstract

Copper-mediated decarboxylative trifluoromethylation provides a new protocol for the efficient preparation of α-trifluoromethyl ketones from propiolic acids. It was found that water is involved as a reactant in the reaction, which is significantly different from the previously reported decarboxylative fluoroalkylation reactions.

Original language	English
Pages (from-to)	3478-3483
Number of pages	6
Journal	Chemical Science
Volume	4
Issue number	9
DOIs	https://doi.org/10.1039/c3sc51613j
State	Published - 29 Jul 2013
Externally published	Yes

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title = "Copper-mediated trifluoromethylation of propiolic acids: Facile synthesis of α-trifluoromethyl ketones",

abstract = "Copper-mediated decarboxylative trifluoromethylation provides a new protocol for the efficient preparation of α-trifluoromethyl ketones from propiolic acids. It was found that water is involved as a reactant in the reaction, which is significantly different from the previously reported decarboxylative fluoroalkylation reactions.",

author = "Zhengbiao He and Rui Zhang and Mingyou Hu and Lingchun Li and Chuanfa Ni and Jinbo Hu",

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T2 - Facile synthesis of α-trifluoromethyl ketones

AU - He, Zhengbiao

AU - Zhang, Rui

AU - Hu, Mingyou

AU - Li, Lingchun

AU - Ni, Chuanfa

AU - Hu, Jinbo

PY - 2013/7/29

Y1 - 2013/7/29

N2 - Copper-mediated decarboxylative trifluoromethylation provides a new protocol for the efficient preparation of α-trifluoromethyl ketones from propiolic acids. It was found that water is involved as a reactant in the reaction, which is significantly different from the previously reported decarboxylative fluoroalkylation reactions.

AB - Copper-mediated decarboxylative trifluoromethylation provides a new protocol for the efficient preparation of α-trifluoromethyl ketones from propiolic acids. It was found that water is involved as a reactant in the reaction, which is significantly different from the previously reported decarboxylative fluoroalkylation reactions.

UR - https://www.scopus.com/pages/publications/84886821536

U2 - 10.1039/c3sc51613j

DO - 10.1039/c3sc51613j

M3 - 文章

AN - SCOPUS:84886821536

SN - 2041-6520

VL - 4

SP - 3478

EP - 3483

JO - Chemical Science

JF - Chemical Science

IS - 9

ER -

Copper-mediated trifluoromethylation of propiolic acids: Facile synthesis of α-trifluoromethyl ketones

Abstract

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