Copper-Mediated Deuterotrifluoromethylation of α?Diazo Esters

Mingyou Hu; Qiqiang Xie; Xinjin Li; Chuanfa Ni; Jinbo Hu

doi:10.1002/cjoc.201600004

Copper-Mediated Deuterotrifluoromethylation of α?Diazo Esters

Mingyou Hu
, Qiqiang Xie
, Xinjin Li
, Chuanfa Ni
, Jinbo Hu

CAS - Shanghai Institute of Organic Chemistry

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A copper-mediated deuterotrifluoromethylation of α?diazo esters under the promotion of deuterium oxide (D₂O) has been developed for the synthesis of deuterium-labeled trifluoromethyl compounds. This deuterotrifluoromethylation reaction is of broad scope and can afford the deuterated products with higher than 99% isotopic purity. Moreover, the results of this investigation also provide some experimental evidences to support our previously proposed trifluoromethylation mechanism.

Original language	English
Pages (from-to)	469-472
Number of pages	4
Journal	Chinese Journal of Chemistry
Volume	34
Issue number	5
DOIs	https://doi.org/10.1002/cjoc.201600004
State	Published - 1 May 2016
Externally published	Yes

Keywords

copper
deuterium
diazo compounds
trifluoromethylation

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10.1002/cjoc.201600004

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@article{00083812d96643c3a630cd5bd92580dc,

title = "Copper-Mediated Deuterotrifluoromethylation of α?Diazo Esters",

abstract = "A copper-mediated deuterotrifluoromethylation of α?diazo esters under the promotion of deuterium oxide (D2O) has been developed for the synthesis of deuterium-labeled trifluoromethyl compounds. This deuterotrifluoromethylation reaction is of broad scope and can afford the deuterated products with higher than 99\% isotopic purity. Moreover, the results of this investigation also provide some experimental evidences to support our previously proposed trifluoromethylation mechanism.",

keywords = "copper, deuterium, diazo compounds, trifluoromethylation",

author = "Mingyou Hu and Qiqiang Xie and Xinjin Li and Chuanfa Ni and Jinbo Hu",

note = "Publisher Copyright: {\textcopyright} 2016 SIOC, CAS, Shanghai \& Wiley-VCH Verlag GmbH \& Co. KGaA, Weinheim.",

year = "2016",

month = may,

day = "1",

doi = "10.1002/cjoc.201600004",

language = "英语",

volume = "34",

pages = "469--472",

journal = "Chinese Journal of Chemistry",

issn = "1001-604X",

publisher = "John Wiley and Sons Inc",

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}

TY - JOUR

T1 - Copper-Mediated Deuterotrifluoromethylation of α?Diazo Esters

AU - Hu, Mingyou

AU - Xie, Qiqiang

AU - Li, Xinjin

AU - Ni, Chuanfa

AU - Hu, Jinbo

PY - 2016/5/1

Y1 - 2016/5/1

N2 - A copper-mediated deuterotrifluoromethylation of α?diazo esters under the promotion of deuterium oxide (D2O) has been developed for the synthesis of deuterium-labeled trifluoromethyl compounds. This deuterotrifluoromethylation reaction is of broad scope and can afford the deuterated products with higher than 99% isotopic purity. Moreover, the results of this investigation also provide some experimental evidences to support our previously proposed trifluoromethylation mechanism.

AB - A copper-mediated deuterotrifluoromethylation of α?diazo esters under the promotion of deuterium oxide (D2O) has been developed for the synthesis of deuterium-labeled trifluoromethyl compounds. This deuterotrifluoromethylation reaction is of broad scope and can afford the deuterated products with higher than 99% isotopic purity. Moreover, the results of this investigation also provide some experimental evidences to support our previously proposed trifluoromethylation mechanism.

KW - copper

KW - deuterium

KW - diazo compounds

KW - trifluoromethylation

UR - https://www.scopus.com/pages/publications/84964469228

U2 - 10.1002/cjoc.201600004

DO - 10.1002/cjoc.201600004

M3 - 文章

AN - SCOPUS:84964469228

SN - 1001-604X

VL - 34

SP - 469

EP - 472

JO - Chinese Journal of Chemistry

JF - Chinese Journal of Chemistry

IS - 5

ER -

Copper-Mediated Deuterotrifluoromethylation of α?Diazo Esters

Abstract

Keywords

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