Copper-catalyzed redox neutral ketoalkylation of Csp2-H bonds: Via C-C bond cleavage

He Chen; Li Na Guo; Qing Xin Sun; Lei Chen; Jing Qi Tao; Pin Gao

doi:10.1039/d1qo00882j

Copper-catalyzed redox neutral ketoalkylation of Csp²-H bonds: Via C-C bond cleavage

He Chen
, Li Na Guo
, Qing Xin Sun
, Lei Chen
, Jing Qi Tao
, Pin Gao

School of Chemistry

Xi'an Jiaotong University

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

An efficient copper-catalyzed ketoalkylation of Csp2-H bonds with cycloalkyl silyl peroxides under mild and redox neutral conditions is presented. Relying on the C-C bond cleavage, a series of distal ketoalkyl moieties were successfully incorporated into the specific position of quinoxalin-2(1H)-ones, heteroaromatic N-oxides and quinones with moderate to good yields.

Original language	English
Pages (from-to)	5866-5871
Number of pages	6
Journal	Organic Chemistry Frontiers
Volume	8
Issue number	20
DOIs	https://doi.org/10.1039/d1qo00882j
State	Published - 21 Oct 2021

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title = "Copper-catalyzed redox neutral ketoalkylation of Csp2-H bonds: Via C-C bond cleavage",

abstract = "An efficient copper-catalyzed ketoalkylation of Csp2-H bonds with cycloalkyl silyl peroxides under mild and redox neutral conditions is presented. Relying on the C-C bond cleavage, a series of distal ketoalkyl moieties were successfully incorporated into the specific position of quinoxalin-2(1H)-ones, heteroaromatic N-oxides and quinones with moderate to good yields.",

author = "He Chen and Guo, \{Li Na\} and Sun, \{Qing Xin\} and Lei Chen and Tao, \{Jing Qi\} and Pin Gao",

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language = "英语",

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T1 - Copper-catalyzed redox neutral ketoalkylation of Csp2-H bonds

T2 - Via C-C bond cleavage

AU - Chen, He

AU - Guo, Li Na

AU - Sun, Qing Xin

AU - Chen, Lei

AU - Tao, Jing Qi

AU - Gao, Pin

PY - 2021/10/21

Y1 - 2021/10/21

N2 - An efficient copper-catalyzed ketoalkylation of Csp2-H bonds with cycloalkyl silyl peroxides under mild and redox neutral conditions is presented. Relying on the C-C bond cleavage, a series of distal ketoalkyl moieties were successfully incorporated into the specific position of quinoxalin-2(1H)-ones, heteroaromatic N-oxides and quinones with moderate to good yields.

AB - An efficient copper-catalyzed ketoalkylation of Csp2-H bonds with cycloalkyl silyl peroxides under mild and redox neutral conditions is presented. Relying on the C-C bond cleavage, a series of distal ketoalkyl moieties were successfully incorporated into the specific position of quinoxalin-2(1H)-ones, heteroaromatic N-oxides and quinones with moderate to good yields.

UR - https://www.scopus.com/pages/publications/85117380498

U2 - 10.1039/d1qo00882j

DO - 10.1039/d1qo00882j

M3 - 文章

AN - SCOPUS:85117380498

SN - 2052-4110

VL - 8

SP - 5866

EP - 5871

JO - Organic Chemistry Frontiers

JF - Organic Chemistry Frontiers

IS - 20

ER -

Copper-catalyzed redox neutral ketoalkylation of Csp²-H bonds: Via C-C bond cleavage

Abstract

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