Copper-catalyzed radical ring-opening halogenation with HX

Shuai Liu; Ming Bai; Peng Fei Xu; Qing Xin Sun; Xin Hua Duan; Li Na Guo

doi:10.1039/d1cc03013b

Copper-catalyzed radical ring-opening halogenation with HX

Shuai Liu
, Ming Bai
, Peng Fei Xu
, Qing Xin Sun
, Xin Hua Duan
, Li Na Guo

School of Chemistry

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

An efficient copper-catalyzed radical ring-opening halogenation with HX (aq) is described. This protocol features redox-neutral conditions, green halogen sources, and a broad substrate scope, providing practical access to distally chlorinated, brominated and iodinated alkyl ketones and alkyl nitriles with moderate to good yields.

Original language	English
Pages (from-to)	8652-8655
Number of pages	4
Journal	Chemical Communications
Volume	57
Issue number	69
DOIs	https://doi.org/10.1039/d1cc03013b
State	Published - 7 Sep 2021

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title = "Copper-catalyzed radical ring-opening halogenation with HX",

abstract = "An efficient copper-catalyzed radical ring-opening halogenation with HX (aq) is described. This protocol features redox-neutral conditions, green halogen sources, and a broad substrate scope, providing practical access to distally chlorinated, brominated and iodinated alkyl ketones and alkyl nitriles with moderate to good yields.",

author = "Shuai Liu and Ming Bai and Xu, \{Peng Fei\} and Sun, \{Qing Xin\} and Duan, \{Xin Hua\} and Guo, \{Li Na\}",

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doi = "10.1039/d1cc03013b",

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T1 - Copper-catalyzed radical ring-opening halogenation with HX

AU - Liu, Shuai

AU - Bai, Ming

AU - Xu, Peng Fei

AU - Sun, Qing Xin

AU - Duan, Xin Hua

AU - Guo, Li Na

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2021/9/7

Y1 - 2021/9/7

N2 - An efficient copper-catalyzed radical ring-opening halogenation with HX (aq) is described. This protocol features redox-neutral conditions, green halogen sources, and a broad substrate scope, providing practical access to distally chlorinated, brominated and iodinated alkyl ketones and alkyl nitriles with moderate to good yields.

AB - An efficient copper-catalyzed radical ring-opening halogenation with HX (aq) is described. This protocol features redox-neutral conditions, green halogen sources, and a broad substrate scope, providing practical access to distally chlorinated, brominated and iodinated alkyl ketones and alkyl nitriles with moderate to good yields.

UR - https://www.scopus.com/pages/publications/85114020309

U2 - 10.1039/d1cc03013b

DO - 10.1039/d1cc03013b

M3 - 文章

C2 - 34373865

AN - SCOPUS:85114020309

SN - 1359-7345

VL - 57

SP - 8652

EP - 8655

JO - Chemical Communications

JF - Chemical Communications

IS - 69

ER -

Copper-catalyzed radical ring-opening halogenation with HX

Abstract

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