TY - JOUR
T1 - Copper-Catalyzed Cyanoalkylation of Amines via C-C Bond Cleavage
T2 - An Approach for C(sp3)-N Bond Formations
AU - Yang, Lin
AU - Zhang, Jia Yu
AU - Duan, Xin Hua
AU - Gao, Pin
AU - Jiao, Jiao
AU - Guo, Li Na
N1 - Publisher Copyright:
© 2019 American Chemical Society.
PY - 2019/7/5
Y1 - 2019/7/5
N2 - The efficient copper-catalyzed cyanoalkylation of amines via C-C bond cleavage has been demonstrated. Distinctive features of this procedure involves mild conditions, broad range of nitrogen nucleophiles, high selectivity, and good functional group tolerance, thus providing a useful approach for the C(sp3)-N bond formations. Most importantly, this protocol is applicable to the late-stage functionalization of natural products, amino acid esters, and drugs. Mechanistic studies suggest that a radical intermediate was involved in this transformation.
AB - The efficient copper-catalyzed cyanoalkylation of amines via C-C bond cleavage has been demonstrated. Distinctive features of this procedure involves mild conditions, broad range of nitrogen nucleophiles, high selectivity, and good functional group tolerance, thus providing a useful approach for the C(sp3)-N bond formations. Most importantly, this protocol is applicable to the late-stage functionalization of natural products, amino acid esters, and drugs. Mechanistic studies suggest that a radical intermediate was involved in this transformation.
UR - https://www.scopus.com/pages/publications/85069270381
U2 - 10.1021/acs.joc.9b01084
DO - 10.1021/acs.joc.9b01084
M3 - 文章
C2 - 31244152
AN - SCOPUS:85069270381
SN - 0022-3263
VL - 84
SP - 8615
EP - 8629
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 13
ER -