Controlling plasma-activated solution chemistry for targeted cancer cell death

Zhijie Liu; Xiamin Tantai; Sitao Wang; Bolun Pang; Yuting Gao; Feng Zhang; Xinyi Zhao; Dehui Xu; Aswathi Soni; Anne Mai-Prochnow; Patrick Cullen; Renwu Zhou

doi:10.1002/ppap.202300029

Controlling plasma-activated solution chemistry for targeted cancer cell death

Zhijie Liu
, Xiamin Tantai
, Sitao Wang
, Bolun Pang
, Yuting Gao
, Feng Zhang
, Xinyi Zhao
, Dehui Xu
, Aswathi Soni
, Anne Mai-Prochnow
, Patrick Cullen
, Renwu Zhou

School of Electrical Engineering

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Plasma-activated solutions (PAS) are attracting attention in biomedicine, however their complexity necessitates a greater understanding of both the plasma activation process and the selected starting solution. Here, five solutions, including deionized water, saline, PB, PBS, and RPMI 1640, were treated to investigate the physicochemical properties and anticancer effects. The findings show that the different solutions largely affected the gas–liquid interaction reactions and the color penetration distribution of H₂O₂ and NO₂⁻. The anticancer effects are in the order of DI > PB≈saline> PBS > RPMI 1640, attributed to the important role of H₂O₂ and NO₂⁻ in inactivating cancer cells. This study provides insights into designing and applying PAS in practical anticancer therapy.

Original language	English
Article number	e2300029
Journal	Plasma Processes and Polymers
Volume	20
Issue number	10
DOIs	https://doi.org/10.1002/ppap.202300029
State	Published - Oct 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

anticancer effects
aqueous chemistry
plasma-activated solutions
plasma–liquid interactions reactive oxygen and nitrogen species (RONS)

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10.1002/ppap.202300029

Cite this

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title = "Controlling plasma-activated solution chemistry for targeted cancer cell death",

abstract = "Plasma-activated solutions (PAS) are attracting attention in biomedicine, however their complexity necessitates a greater understanding of both the plasma activation process and the selected starting solution. Here, five solutions, including deionized water, saline, PB, PBS, and RPMI 1640, were treated to investigate the physicochemical properties and anticancer effects. The findings show that the different solutions largely affected the gas–liquid interaction reactions and the color penetration distribution of H2O2 and NO2−. The anticancer effects are in the order of DI > PB≈saline> PBS > RPMI 1640, attributed to the important role of H2O2 and NO2− in inactivating cancer cells. This study provides insights into designing and applying PAS in practical anticancer therapy.",

keywords = "anticancer effects, aqueous chemistry, plasma-activated solutions, plasma–liquid interactions reactive oxygen and nitrogen species (RONS)",

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doi = "10.1002/ppap.202300029",

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T1 - Controlling plasma-activated solution chemistry for targeted cancer cell death

AU - Liu, Zhijie

AU - Tantai, Xiamin

AU - Wang, Sitao

AU - Pang, Bolun

AU - Gao, Yuting

AU - Zhang, Feng

AU - Zhao, Xinyi

AU - Xu, Dehui

AU - Soni, Aswathi

AU - Mai-Prochnow, Anne

AU - Cullen, Patrick

AU - Zhou, Renwu

PY - 2023/10

Y1 - 2023/10

N2 - Plasma-activated solutions (PAS) are attracting attention in biomedicine, however their complexity necessitates a greater understanding of both the plasma activation process and the selected starting solution. Here, five solutions, including deionized water, saline, PB, PBS, and RPMI 1640, were treated to investigate the physicochemical properties and anticancer effects. The findings show that the different solutions largely affected the gas–liquid interaction reactions and the color penetration distribution of H2O2 and NO2−. The anticancer effects are in the order of DI > PB≈saline> PBS > RPMI 1640, attributed to the important role of H2O2 and NO2− in inactivating cancer cells. This study provides insights into designing and applying PAS in practical anticancer therapy.

AB - Plasma-activated solutions (PAS) are attracting attention in biomedicine, however their complexity necessitates a greater understanding of both the plasma activation process and the selected starting solution. Here, five solutions, including deionized water, saline, PB, PBS, and RPMI 1640, were treated to investigate the physicochemical properties and anticancer effects. The findings show that the different solutions largely affected the gas–liquid interaction reactions and the color penetration distribution of H2O2 and NO2−. The anticancer effects are in the order of DI > PB≈saline> PBS > RPMI 1640, attributed to the important role of H2O2 and NO2− in inactivating cancer cells. This study provides insights into designing and applying PAS in practical anticancer therapy.

KW - anticancer effects

KW - aqueous chemistry

KW - plasma-activated solutions

KW - plasma–liquid interactions reactive oxygen and nitrogen species (RONS)

UR - https://www.scopus.com/pages/publications/85161607036

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DO - 10.1002/ppap.202300029

M3 - 文章

AN - SCOPUS:85161607036

SN - 1612-8850

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JO - Plasma Processes and Polymers

JF - Plasma Processes and Polymers

IS - 10

M1 - e2300029

ER -

Controlling plasma-activated solution chemistry for targeted cancer cell death

Abstract

UN SDGs

Keywords

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