Abstract
Facilitating chemistry: Key to the success of Pd-catalyzed α-arylation of oxindoles in continuous flow involved a biphasic system, a precatalyst, and a packed-bed microreactor. Furthermore, this reaction was integrated into a two-step continuous-flow sequence for rapid, modular, and efficient syntheses of 3,3-disubstituted oxindoles.
| Original language | English |
|---|---|
| Pages (from-to) | 6396-6400 |
| Number of pages | 5 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 50 |
| Issue number | 28 |
| DOIs | |
| State | Published - 4 Jul 2011 |
| Externally published | Yes |
Keywords
- biphasic catalysis
- continuous flow
- multistep reactions
- oxindole
- α-arylation