Abstract
The assumption of fixed-effects model is based on that the true effect of the each trial is same. However, the assumption of random-effects model is based on that the true effect of included trials is normal distributed. The total variance is equal to the sum of within-trial variance and between-trial variance under the random-effects model. There are many estimators of the between-trial variance. The aim of this paper is to give a brief introduction of the estimators of between-trial variance in trial sequential analysis for random-effects model.
| Original language | English |
|---|---|
| Pages (from-to) | 369-372 |
| Number of pages | 4 |
| Journal | Chinese Journal of Evidence-Based Medicine |
| Volume | 17 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2017 |
| Externally published | Yes |
Keywords
- Between-trial variance
- Heterogeneity
- Meta-analysis
- Random-effects model
- Trial sequential analysis