Comparative study on different effects of three bionic microstructures of artificial bone

An approach of fabricating artificial bone with fibre-reinforced composite by 3D braiding technology based on rapid prototyping (RP) is presented, where the fibres are braided into helical, perpendicular and concentric structure respectively to prepare artificial bones, and the characteristics in special molds and fibre structure are listed. Furthermore, effects of different fibre structures on improving bone regeneration and degradation of artificial bones are explored by analyzing the X-ray photographs, histological sections and percentage composition during canine radio defect repairing, and the internal perpendicular and concentric fibre structure of artificial bone can be precisely controlled. In the process of bone repairing, all of implants with three fibre structures enable to provide enough mechanical strength initially, the percent loss approaches to the lowest in helix structure implants, and the percent bone ingrowth reaches to the highest in concentric structure implants. This kind of artificial bone, constituted by chitosan, bone morphogenic protein and calcium phosphate investment, facilitates bone conduction and bone induction. And the artificial bone with concentric fibre structure possesses the optimal internal architecture due to the best capability of bone regeneration.