TY - JOUR
T1 - Comparative study of MR diffusion weighted imaging for breast with different b values
AU - Chen, Xin
AU - Yan, Rui
AU - Kang, Hua Feng
AU - Guo, You Min
AU - Zhao, Xian
AU - He, Chang An
AU - Zhang, Yi Li
PY - 2009/4
Y1 - 2009/4
N2 - Objective: To explore the optimal b value in MR DWI for breast. Methods: Forty patients with palpable masses of breasts underwent MR and DWI at b = 1000, 800 and 600 s/mm2 before surgery according prospective planning. Visual assessment, signal to noise ratio (SNR) of DWI and the ADC values of benign and malignant lesions were compared among three b values using one-way ANOVA test. The diagnostic value of ADC were analyzed by ROC curves. Results: Of the 40 patients, there were 26 patients with malignant lesions and 14 patients with benign lesions verified by histopathology. 36 patients with 42 lesions were examined by DWI, and detectabilities at three b values were alike. Most DWI at b = 1000, 800 and 600 s/mm2 were of high quality, and images of grade A were 75.0% (30/40), 77.5% (31/40) and 77.5% (31/40), respectively. Mean SNR at b = 1000, 800 and 600 s/mm2 were 63 ± 22, 82 ± 27 and 96 ± 29 respectively. Compared with one another, there was statistically significant difference (P < 0.01). Mean ADC of benign lesions at different b values were (1.44 ± 0.28) × 10-3, (1.50 ± 0.32) × 10-3 and (1.52 ± 0.29) × 10 -3 mm2/s respectively. Compared with one another, there was no statistically significant difference (P = 0.725). Mean ADC of malignant lesions were (1.00 ± 0.25) × 10-3, (0.98 ± 0.19) × 10-3 and (1.07 ± 0.22) × 10-3 mm 2/s respectively. Compared with one another, there was also no statistically significant difference (P = 0.358). The area under the ROC curves at b = 1000, 800 and 600 s/mm2 were 0.879, 0.885 and 0.865 respectively. Threshold value to distinguish benign and malignant lesions were 1.295 × 10-3, 1.435 × 10-3 and 1.335 × 10-3 mm2/s respectively. Sensitivity of diagnosing breast cancer were 80.0%, 92.0% and 84.0%, and specificity were all 90.0%. Positive predictive values were 95.2%, 95.8% and 95.5% at b = 1000, 800 and 600 s/mm 2. Conclusion: Combining SNR and the value of ADC in diagnosing benign and malignant breast lesions, the study indicated that b = 800 s/mm 2 was the optimal b value in breast DWI.
AB - Objective: To explore the optimal b value in MR DWI for breast. Methods: Forty patients with palpable masses of breasts underwent MR and DWI at b = 1000, 800 and 600 s/mm2 before surgery according prospective planning. Visual assessment, signal to noise ratio (SNR) of DWI and the ADC values of benign and malignant lesions were compared among three b values using one-way ANOVA test. The diagnostic value of ADC were analyzed by ROC curves. Results: Of the 40 patients, there were 26 patients with malignant lesions and 14 patients with benign lesions verified by histopathology. 36 patients with 42 lesions were examined by DWI, and detectabilities at three b values were alike. Most DWI at b = 1000, 800 and 600 s/mm2 were of high quality, and images of grade A were 75.0% (30/40), 77.5% (31/40) and 77.5% (31/40), respectively. Mean SNR at b = 1000, 800 and 600 s/mm2 were 63 ± 22, 82 ± 27 and 96 ± 29 respectively. Compared with one another, there was statistically significant difference (P < 0.01). Mean ADC of benign lesions at different b values were (1.44 ± 0.28) × 10-3, (1.50 ± 0.32) × 10-3 and (1.52 ± 0.29) × 10 -3 mm2/s respectively. Compared with one another, there was no statistically significant difference (P = 0.725). Mean ADC of malignant lesions were (1.00 ± 0.25) × 10-3, (0.98 ± 0.19) × 10-3 and (1.07 ± 0.22) × 10-3 mm 2/s respectively. Compared with one another, there was also no statistically significant difference (P = 0.358). The area under the ROC curves at b = 1000, 800 and 600 s/mm2 were 0.879, 0.885 and 0.865 respectively. Threshold value to distinguish benign and malignant lesions were 1.295 × 10-3, 1.435 × 10-3 and 1.335 × 10-3 mm2/s respectively. Sensitivity of diagnosing breast cancer were 80.0%, 92.0% and 84.0%, and specificity were all 90.0%. Positive predictive values were 95.2%, 95.8% and 95.5% at b = 1000, 800 and 600 s/mm 2. Conclusion: Combining SNR and the value of ADC in diagnosing benign and malignant breast lesions, the study indicated that b = 800 s/mm 2 was the optimal b value in breast DWI.
KW - Breast disease
KW - Diffusion magnetic resonance imaging
UR - https://www.scopus.com/pages/publications/67651068650
U2 - 10.3760/cma.j.issn.1005-1201.2009.04.006
DO - 10.3760/cma.j.issn.1005-1201.2009.04.006
M3 - 文章
AN - SCOPUS:67651068650
SN - 1005-1201
VL - 43
SP - 356
EP - 359
JO - Chinese Journal of Radiology (China)
JF - Chinese Journal of Radiology (China)
IS - 4
ER -
