Colorimetric and luminescent dual-signaling responsive probing of thiols by a ruthenium(II)-azo complex

Guan Ying Li; Jiang Ping Liu; Huai Yi Huang; Ya Wen; Hui Chao; Liang Nian Ji

doi:10.1016/j.jinorgbio.2012.12.019

Colorimetric and luminescent dual-signaling responsive probing of thiols by a ruthenium(II)-azo complex

Guan Ying Li
, Jiang Ping Liu
, Huai Yi Huang
, Ya Wen
, Hui Chao
, Liang Nian Ji

Sun Yat-Sen University

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

A dinuclear ruthenium(II) complex linked via a reducible azo group [Ru(bpy)₂(azobpy)Ru(bpy)₂]Cl₄ (Ru ₂azo, bpy = 2,2′-bipyridine, azobpy = 4,4″-azobis (2,2′-bipyridine)) was adopted as a probe for thiols. Results showed that Ru₂azo could selectively and effectively react with biological thiols (such as cysteine, homocysteine and glutathione) with a 10^{- 7} M detection limit. After it reacted with thiols, the original gray color of Ru₂azo solution immediately turned yellow and the luminescence significantly enhanced, showing "naked-eye" colorimetric and "off-on" luminescent dual-signaling response for thiols. Mechanism studies demonstrated that Ru₂azo reacted with thiols undergoing a two-electron transfer process, forming the azo^{2 -} anion product.

Original language	English
Pages (from-to)	108-113
Number of pages	6
Journal	Journal of Inorganic Biochemistry
Volume	121
DOIs	https://doi.org/10.1016/j.jinorgbio.2012.12.019
State	Published - Apr 2013
Externally published	Yes

Keywords

Azo
Biological thiols
Chemosensor
Redox reaction
Ruthenium(II) complex

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10.1016/j.jinorgbio.2012.12.019

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@article{3fc05d572dab415589b692355a199b3d,

title = "Colorimetric and luminescent dual-signaling responsive probing of thiols by a ruthenium(II)-azo complex",

abstract = "A dinuclear ruthenium(II) complex linked via a reducible azo group [Ru(bpy)2(azobpy)Ru(bpy)2]Cl4 (Ru 2azo, bpy = 2,2′-bipyridine, azobpy = 4,4″-azobis (2,2′-bipyridine)) was adopted as a probe for thiols. Results showed that Ru2azo could selectively and effectively react with biological thiols (such as cysteine, homocysteine and glutathione) with a 10- 7 M detection limit. After it reacted with thiols, the original gray color of Ru2azo solution immediately turned yellow and the luminescence significantly enhanced, showing {"}naked-eye{"} colorimetric and {"}off-on{"} luminescent dual-signaling response for thiols. Mechanism studies demonstrated that Ru2azo reacted with thiols undergoing a two-electron transfer process, forming the azo2 - anion product.",

keywords = "Azo, Biological thiols, Chemosensor, Redox reaction, Ruthenium(II) complex",

author = "Li, \{Guan Ying\} and Liu, \{Jiang Ping\} and Huang, \{Huai Yi\} and Ya Wen and Hui Chao and Ji, \{Liang Nian\}",

year = "2013",

month = apr,

doi = "10.1016/j.jinorgbio.2012.12.019",

language = "英语",

volume = "121",

pages = "108--113",

journal = "Journal of Inorganic Biochemistry",

issn = "0162-0134",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Colorimetric and luminescent dual-signaling responsive probing of thiols by a ruthenium(II)-azo complex

AU - Li, Guan Ying

AU - Liu, Jiang Ping

AU - Huang, Huai Yi

AU - Wen, Ya

AU - Chao, Hui

AU - Ji, Liang Nian

PY - 2013/4

Y1 - 2013/4

N2 - A dinuclear ruthenium(II) complex linked via a reducible azo group [Ru(bpy)2(azobpy)Ru(bpy)2]Cl4 (Ru 2azo, bpy = 2,2′-bipyridine, azobpy = 4,4″-azobis (2,2′-bipyridine)) was adopted as a probe for thiols. Results showed that Ru2azo could selectively and effectively react with biological thiols (such as cysteine, homocysteine and glutathione) with a 10- 7 M detection limit. After it reacted with thiols, the original gray color of Ru2azo solution immediately turned yellow and the luminescence significantly enhanced, showing "naked-eye" colorimetric and "off-on" luminescent dual-signaling response for thiols. Mechanism studies demonstrated that Ru2azo reacted with thiols undergoing a two-electron transfer process, forming the azo2 - anion product.

AB - A dinuclear ruthenium(II) complex linked via a reducible azo group [Ru(bpy)2(azobpy)Ru(bpy)2]Cl4 (Ru 2azo, bpy = 2,2′-bipyridine, azobpy = 4,4″-azobis (2,2′-bipyridine)) was adopted as a probe for thiols. Results showed that Ru2azo could selectively and effectively react with biological thiols (such as cysteine, homocysteine and glutathione) with a 10- 7 M detection limit. After it reacted with thiols, the original gray color of Ru2azo solution immediately turned yellow and the luminescence significantly enhanced, showing "naked-eye" colorimetric and "off-on" luminescent dual-signaling response for thiols. Mechanism studies demonstrated that Ru2azo reacted with thiols undergoing a two-electron transfer process, forming the azo2 - anion product.

KW - Azo

KW - Biological thiols

KW - Chemosensor

KW - Redox reaction

KW - Ruthenium(II) complex

UR - https://www.scopus.com/pages/publications/84873038354

U2 - 10.1016/j.jinorgbio.2012.12.019

DO - 10.1016/j.jinorgbio.2012.12.019

M3 - 文章

C2 - 23376332

AN - SCOPUS:84873038354

SN - 0162-0134

VL - 121

SP - 108

EP - 113

JO - Journal of Inorganic Biochemistry

JF - Journal of Inorganic Biochemistry

ER -

Colorimetric and luminescent dual-signaling responsive probing of thiols by a ruthenium(II)-azo complex

Abstract

Keywords

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