Cohesin RAD21 Gene Promoter Methylation Correlated with Better Prognosis in Breast Cancer Patients

Rongrong Cui; Pu Chen; Yuanyuan Wang; Rong Lu; Meiju Ji; Peng Hou; Yiping Qu

doi:10.1159/000524735

Cohesin RAD21 Gene Promoter Methylation Correlated with Better Prognosis in Breast Cancer Patients

Rongrong Cui
, Pu Chen
, Yuanyuan Wang
, Rong Lu
, Meiju Ji
, Peng Hou
, Yiping Qu

The First Affiliated Hospital of Xi’an Jiaotong University

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

RAD21 plays multiple roles in numerous cancers. In breast cancer (BC), a high level of RAD21 correlates with poor disease outcomes and resistance to chemotherapy. However, data regarding RAD21 promoter methylation in BC tissue and its correlation with clinical outcomes in patients with BC remain limited. Here, we investigated the clinicopathological features associated with the methylation status of RAD21 in BC to figure out its possible role in pathogenesis and the formation of breast carcinogenesis. The methylation status of the RAD21 gene was significantly associated with better clinical outcomes in patients with BC.

Original language	English
Pages (from-to)	109-118
Number of pages	10
Journal	Cytogenetic and Genome Research
Volume	162
Issue number	3
DOIs	https://doi.org/10.1159/000524735
State	Published - 1 Oct 2022
Externally published	Yes

Keywords

Breast cancer
Clinical outcomes
Methylation-specific PCR
Promotor methylation
RAD21

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1159/000524735

Cite this

@article{6156a443d12d4381aa6d0b75c47bce88,

title = "Cohesin RAD21 Gene Promoter Methylation Correlated with Better Prognosis in Breast Cancer Patients",

abstract = "RAD21 plays multiple roles in numerous cancers. In breast cancer (BC), a high level of RAD21 correlates with poor disease outcomes and resistance to chemotherapy. However, data regarding RAD21 promoter methylation in BC tissue and its correlation with clinical outcomes in patients with BC remain limited. Here, we investigated the clinicopathological features associated with the methylation status of RAD21 in BC to figure out its possible role in pathogenesis and the formation of breast carcinogenesis. The methylation status of the RAD21 gene was significantly associated with better clinical outcomes in patients with BC.",

keywords = "Breast cancer, Clinical outcomes, Methylation-specific PCR, Promotor methylation, RAD21",

author = "Rongrong Cui and Pu Chen and Yuanyuan Wang and Rong Lu and Meiju Ji and Peng Hou and Yiping Qu",

note = "Publisher Copyright: {\textcopyright} 2022 ",

year = "2022",

month = oct,

day = "1",

doi = "10.1159/000524735",

language = "英语",

volume = "162",

pages = "109--118",

journal = "Cytogenetic and Genome Research",

issn = "1424-8581",

publisher = "S. Karger AG",

number = "3",

}

TY - JOUR

T1 - Cohesin RAD21 Gene Promoter Methylation Correlated with Better Prognosis in Breast Cancer Patients

AU - Cui, Rongrong

AU - Chen, Pu

AU - Wang, Yuanyuan

AU - Lu, Rong

AU - Ji, Meiju

AU - Hou, Peng

AU - Qu, Yiping

PY - 2022/10/1

Y1 - 2022/10/1

N2 - RAD21 plays multiple roles in numerous cancers. In breast cancer (BC), a high level of RAD21 correlates with poor disease outcomes and resistance to chemotherapy. However, data regarding RAD21 promoter methylation in BC tissue and its correlation with clinical outcomes in patients with BC remain limited. Here, we investigated the clinicopathological features associated with the methylation status of RAD21 in BC to figure out its possible role in pathogenesis and the formation of breast carcinogenesis. The methylation status of the RAD21 gene was significantly associated with better clinical outcomes in patients with BC.

AB - RAD21 plays multiple roles in numerous cancers. In breast cancer (BC), a high level of RAD21 correlates with poor disease outcomes and resistance to chemotherapy. However, data regarding RAD21 promoter methylation in BC tissue and its correlation with clinical outcomes in patients with BC remain limited. Here, we investigated the clinicopathological features associated with the methylation status of RAD21 in BC to figure out its possible role in pathogenesis and the formation of breast carcinogenesis. The methylation status of the RAD21 gene was significantly associated with better clinical outcomes in patients with BC.

KW - Breast cancer

KW - Clinical outcomes

KW - Methylation-specific PCR

KW - Promotor methylation

KW - RAD21

UR - https://www.scopus.com/pages/publications/85131864532

U2 - 10.1159/000524735

DO - 10.1159/000524735

M3 - 文章

C2 - 35654004

AN - SCOPUS:85131864532

SN - 1424-8581

VL - 162

SP - 109

EP - 118

JO - Cytogenetic and Genome Research

JF - Cytogenetic and Genome Research

IS - 3

ER -

Cohesin RAD21 Gene Promoter Methylation Correlated with Better Prognosis in Breast Cancer Patients

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this