TY - JOUR
T1 - Coexisting overexpression of STOML1 and STOML2 proteins may be associated with pathology of oral squamous cell carcinoma
AU - Wang, Daiwei
AU - Qi, Hong
AU - Li, Ang
AU - Deng, Fang
AU - Xu, Ying
AU - Hu, Zhangli
AU - Liu, Qiong
AU - Wang, Yun
N1 - Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/6
Y1 - 2020/6
N2 - Objective: The present study aimed to investigate the expression and co-localization of stomatin-like protein-1 (STOML1) and stomatin-like protein-2 (STOML2) in oral squamous cell carcinoma (OSCC) tissues in situ and evaluate their pathologic roles in OSCC. Study Design: STOML1 and STOML2 in human OSCC tissues (n = 109) and normal oral/paracancerous tissues (n = 19) were detected by using multiple immunohistochemistry (IHC) staining. Positive staining scores and clinicopathologic features during the OSCC process were analyzed. Results: STOML1 and STOML2 were significantly overexpressed in OSCC tissues compared with normal oral tissue/paracancerous tissues (P <.0001 and P <.0001, respectively). Furthermore, both STOML1 and STOML2 were positively associated with pathologic tumor (T) stages. Positive signals of both STOML1 and STOML2 were mainly localized to the cell membrane and the cytoplasm, whereas those of STOML1 were also expressed in the cell nucleus. Conclusions: Our results indicated that overexpression of STOML1 and STOML2 was significantly associated with T1 and T2 stages of OSCC. STOML1 and STOML2 were mainly co-localized at the cell membrane and the cytoplasm. These findings suggested that either STOML1 or STOML2 may play critical roles in OSCC development and may serve as potential diagnostic biomarkers and therapeutic targets.
AB - Objective: The present study aimed to investigate the expression and co-localization of stomatin-like protein-1 (STOML1) and stomatin-like protein-2 (STOML2) in oral squamous cell carcinoma (OSCC) tissues in situ and evaluate their pathologic roles in OSCC. Study Design: STOML1 and STOML2 in human OSCC tissues (n = 109) and normal oral/paracancerous tissues (n = 19) were detected by using multiple immunohistochemistry (IHC) staining. Positive staining scores and clinicopathologic features during the OSCC process were analyzed. Results: STOML1 and STOML2 were significantly overexpressed in OSCC tissues compared with normal oral tissue/paracancerous tissues (P <.0001 and P <.0001, respectively). Furthermore, both STOML1 and STOML2 were positively associated with pathologic tumor (T) stages. Positive signals of both STOML1 and STOML2 were mainly localized to the cell membrane and the cytoplasm, whereas those of STOML1 were also expressed in the cell nucleus. Conclusions: Our results indicated that overexpression of STOML1 and STOML2 was significantly associated with T1 and T2 stages of OSCC. STOML1 and STOML2 were mainly co-localized at the cell membrane and the cytoplasm. These findings suggested that either STOML1 or STOML2 may play critical roles in OSCC development and may serve as potential diagnostic biomarkers and therapeutic targets.
UR - https://www.scopus.com/pages/publications/85084506821
U2 - 10.1016/j.oooo.2020.01.011
DO - 10.1016/j.oooo.2020.01.011
M3 - 文章
C2 - 32402568
AN - SCOPUS:85084506821
SN - 2212-4403
VL - 129
SP - 591-599.e3
JO - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
JF - Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
IS - 6
ER -