Abstract
Objective: To analyze the expression of neuropilin-1 (NRP-1) in gastric cancer tissues and assess its clinicopathological parameters and prognostic significance. Methods: NRP-1 expression was determined by immunohistochemistry in specimens of primary cancer tissues and the adjacent non-cancerous tissues in 180 patients with gastric cancer. NRP-1 expression was analyzed by Western blot in gastric cancer tissues and different gastric cancer cell line. Kaplan-Meier plots and Cox's proportional hazards regression model were used to analyze the prognosis of gastric cancer. Results: By immunohistochemistry, the expression of NRP-1 was significantly higher in gastric cancer than that in adjacent noncancerous tissues (P<0.001). High expression of NRP-1 was positively associated with histologic grade, tumor stage, lymph node metastasis and tumor T stage (P<0.05). Multivariate analysis showed that the high expression of NRP-1 was an independent prognostic factor for overall survival. Conclusion: Overexpression of NRP-1 may play an important role in the progression of gastric cancer, and NRP-1 overexpression may serve as a biomarker for poor prognosis of gastric cancer patients.
| Original language | English |
|---|---|
| Pages (from-to) | 82-86 |
| Number of pages | 5 |
| Journal | Journal of Xi'an Jiaotong University (Medical Sciences) |
| Volume | 37 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2016 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Gastric cancer
- Immunohistochemistry
- Multi-factor regression model
- Neuropilin-1 (NRP-1)
- Survival curve
- Western blot
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