Clinical characteristic study of essential hypertension with insulin resistance and the relationship between blood pressure and insulin resistance

Objective: To investigate the clinical characteristics of essential hypertension with insulin resistance(IR) and the relationship between blood pressure(BP) and IR. Methods: 133 patients with essential hypertension were divided into 2 groups:group of abnormal sugar metabolism and group of normal sugar metabolism. Oral glucose tolerance test(OGTT) and insulin release test (IRT) were performed to determine inpaired glucose tolerance (IGT) or hyperinsulinemia. We compared the plasma glucose(GS) insulin(Ins) and InsSI, monitored 24 h BP and investigated the relationship between BP and InsSI in abnormal group. Results: Compared with normal group fasting plasma Ins. 2 hGS and 2 hIns were much higher especially Ins (P<0.01), and had a lower InsSI(P<0.01). Night BP load was higher than that of day in abnormal group. Compared with normal group night BP load and 24 h diastolic BP load were higher (P<0.01). Conclusion: Essential hypertension with IGT and/or hyperinsulinemia indicates IR. InsSI is negatively correlated with night diastolic BP(r = -0.59, P<0.01) and night diastolic BP load(r = -0.37, P<0.05).