Clinical and genomic features of Chinese lung cancer patients with germline mutations

Wenying Peng; Bin Li; Jin Li; Lianpeng Chang; Jing Bai; Yuting Yi; Rongrong Chen; Yanyan Zhang; Chen Chen; Xingxiang Pu; Meilin Jiang; Jia Li; Rui Zhong; Fang Xu; Bolin Chen; Li Xu; Ning Wang; Jiaojiao Huan; Pingping Dai; Yanfang Guan; Ling Yang; Xuefeng Xia; Xin Yi; Jiayin Wang; Fenglei Yu; Lin Wu

doi:10.1038/s41467-022-28840-5

Clinical and genomic features of Chinese lung cancer patients with germline mutations

Wenying Peng
, Bin Li
, Jin Li
, Lianpeng Chang
, Jing Bai
, Yuting Yi
, Rongrong Chen
, Yanyan Zhang
, Chen Chen
, Xingxiang Pu
, Meilin Jiang
, Jia Li
, Rui Zhong
, Fang Xu
, Bolin Chen
, Li Xu
, Ning Wang
, Jiaojiao Huan
, Pingping Dai
, Yanfang Guan

Ling Yang, Xuefeng Xia, Xin Yi, Jiayin Wang, Fenglei Yu, Lin Wu

Faculty of Electronic and Information Engineering

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The germline mutation landscape in Chinese lung cancer patients has not been well defined. In this study, sequencing data of 1,021 cancer genes of 1,794 Chinese lung cancer patients was analyzed. A total of 111 pathogenic or likely pathogenic germline mutations were identified, significantly higher than non-cancer individuals (111/1794 vs. 84/10,588, p < 2.2e-16). BRCA1/2 germline mutations are associated with earlier onset age (median 52.5 vs 60 years-old, p = 0.008). Among 29 cancer disposition genes with germline mutations detected in Chinese cohort and/or TCGA lung cancer cohort, Only 11 from 29 genes are identified in both cohorts and BRCA2 mutations are significantly more common in Chinese cohort (p = 0.015). Chinese patients with germline mutations have different prevalence of somatic KRAS, MET exon 14 skipping and TP53 mutations compared to those without. Our findings suggest potential ethnic and etiologic differences between Western and Asian lung cancer patients.

Original language	English
Article number	1268
Journal	Nature Communications
Volume	13
Issue number	1
DOIs	https://doi.org/10.1038/s41467-022-28840-5
State	Published - Dec 2022

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10.1038/s41467-022-28840-5

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Peng, W., Li, B., Li, J., Chang, L., Bai, J., Yi, Y., Chen, R., Zhang, Y., Chen, C., Pu, X., Jiang, M., Li, J., Zhong, R., Xu, F., Chen, B., Xu, L., Wang, N., Huan, J., Dai, P., ... Wu, L. (2022). Clinical and genomic features of Chinese lung cancer patients with germline mutations. Nature Communications, 13(1), Article 1268. https://doi.org/10.1038/s41467-022-28840-5

@article{311a17e0b1e5402c8b0a12d6a3ad17e3,

title = "Clinical and genomic features of Chinese lung cancer patients with germline mutations",

abstract = "The germline mutation landscape in Chinese lung cancer patients has not been well defined. In this study, sequencing data of 1,021 cancer genes of 1,794 Chinese lung cancer patients was analyzed. A total of 111 pathogenic or likely pathogenic germline mutations were identified, significantly higher than non-cancer individuals (111/1794 vs. 84/10,588, p < 2.2e-16). BRCA1/2 germline mutations are associated with earlier onset age (median 52.5 vs 60 years-old, p = 0.008). Among 29 cancer disposition genes with germline mutations detected in Chinese cohort and/or TCGA lung cancer cohort, Only 11 from 29 genes are identified in both cohorts and BRCA2 mutations are significantly more common in Chinese cohort (p = 0.015). Chinese patients with germline mutations have different prevalence of somatic KRAS, MET exon 14 skipping and TP53 mutations compared to those without. Our findings suggest potential ethnic and etiologic differences between Western and Asian lung cancer patients.",

author = "Wenying Peng and Bin Li and Jin Li and Lianpeng Chang and Jing Bai and Yuting Yi and Rongrong Chen and Yanyan Zhang and Chen Chen and Xingxiang Pu and Meilin Jiang and Jia Li and Rui Zhong and Fang Xu and Bolin Chen and Li Xu and Ning Wang and Jiaojiao Huan and Pingping Dai and Yanfang Guan and Ling Yang and Xuefeng Xia and Xin Yi and Jiayin Wang and Fenglei Yu and Lin Wu",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = dec,

doi = "10.1038/s41467-022-28840-5",

language = "英语",

volume = "13",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Research",

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Peng, W, Li, B, Li, J, Chang, L, Bai, J, Yi, Y, Chen, R, Zhang, Y, Chen, C, Pu, X, Jiang, M, Li, J, Zhong, R, Xu, F, Chen, B, Xu, L, Wang, N, Huan, J, Dai, P, Guan, Y, Yang, L, Xia, X, Yi, X, Wang, J, Yu, F & Wu, L 2022, 'Clinical and genomic features of Chinese lung cancer patients with germline mutations', Nature Communications, vol. 13, no. 1, 1268. https://doi.org/10.1038/s41467-022-28840-5

TY - JOUR

T1 - Clinical and genomic features of Chinese lung cancer patients with germline mutations

AU - Peng, Wenying

AU - Li, Bin

AU - Li, Jin

AU - Chang, Lianpeng

AU - Bai, Jing

AU - Yi, Yuting

AU - Chen, Rongrong

AU - Zhang, Yanyan

AU - Chen, Chen

AU - Pu, Xingxiang

AU - Jiang, Meilin

AU - Li, Jia

AU - Zhong, Rui

AU - Xu, Fang

AU - Chen, Bolin

AU - Xu, Li

AU - Wang, Ning

AU - Huan, Jiaojiao

AU - Dai, Pingping

AU - Guan, Yanfang

AU - Yang, Ling

AU - Xia, Xuefeng

AU - Yi, Xin

AU - Wang, Jiayin

AU - Yu, Fenglei

AU - Wu, Lin

PY - 2022/12

Y1 - 2022/12

N2 - The germline mutation landscape in Chinese lung cancer patients has not been well defined. In this study, sequencing data of 1,021 cancer genes of 1,794 Chinese lung cancer patients was analyzed. A total of 111 pathogenic or likely pathogenic germline mutations were identified, significantly higher than non-cancer individuals (111/1794 vs. 84/10,588, p < 2.2e-16). BRCA1/2 germline mutations are associated with earlier onset age (median 52.5 vs 60 years-old, p = 0.008). Among 29 cancer disposition genes with germline mutations detected in Chinese cohort and/or TCGA lung cancer cohort, Only 11 from 29 genes are identified in both cohorts and BRCA2 mutations are significantly more common in Chinese cohort (p = 0.015). Chinese patients with germline mutations have different prevalence of somatic KRAS, MET exon 14 skipping and TP53 mutations compared to those without. Our findings suggest potential ethnic and etiologic differences between Western and Asian lung cancer patients.

AB - The germline mutation landscape in Chinese lung cancer patients has not been well defined. In this study, sequencing data of 1,021 cancer genes of 1,794 Chinese lung cancer patients was analyzed. A total of 111 pathogenic or likely pathogenic germline mutations were identified, significantly higher than non-cancer individuals (111/1794 vs. 84/10,588, p < 2.2e-16). BRCA1/2 germline mutations are associated with earlier onset age (median 52.5 vs 60 years-old, p = 0.008). Among 29 cancer disposition genes with germline mutations detected in Chinese cohort and/or TCGA lung cancer cohort, Only 11 from 29 genes are identified in both cohorts and BRCA2 mutations are significantly more common in Chinese cohort (p = 0.015). Chinese patients with germline mutations have different prevalence of somatic KRAS, MET exon 14 skipping and TP53 mutations compared to those without. Our findings suggest potential ethnic and etiologic differences between Western and Asian lung cancer patients.

UR - https://www.scopus.com/pages/publications/85126253157

U2 - 10.1038/s41467-022-28840-5

DO - 10.1038/s41467-022-28840-5

M3 - 文章

C2 - 35273153

AN - SCOPUS:85126253157

SN - 2041-1723

VL - 13

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 1268

ER -

Clinical and genomic features of Chinese lung cancer patients with germline mutations

Abstract

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