Characterizing size and porosity of hollow nanoparticles: SAXS, SANS, TEM, DLS, and adsorption isotherms compared

  • Zhi Hong Chen
  • , Chanhoi Kim
  • , Xiang Bing Zeng
  • , Sun Hye Hwang
  • , Jyongsik Jang
  • , Goran Ungar

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

A combination of experimental methods, including transmission and grazing incidence small-angle X-ray scattering (SAXS and GISAXS), small-angle neutron scattering (SANS), transmission electron microscopy (TEM), dynamic light scattering (DLS), and N 2 adsorption-desorption isotherms, was used to characterize SiO 2/TiO 2 hollow nanoparticles (HNPs) of sizes between 25 and 100 nm. In the analysis of SAXS, SANS, and GISAXS data, the decoupling approximation and the Percus-Yevick structure factor approximation were used. Brunauer-Emmett-Teller, t-plot, and a spherical pore model based on Kelvin equation were applied in the treatment of N 2 isotherms. Extracted parameters from the scattering and TEM methods are the average outer and inner diameters and polydispersity. Good agreement was achieved between different methods for these extracted parameters. Merits, advantages, and disadvantages of the different methods are discussed. Furthermore, the combination of these methods provided us with information on the porosity of the shells of HNPs and the size of intrawall pores, which are critical to the applications of HNPs as drug delivery vehicles and catalyst supports.

Original languageEnglish
Pages (from-to)15350-15361
Number of pages12
JournalLangmuir
Volume28
Issue number43
DOIs
StatePublished - 30 Oct 2012
Externally publishedYes

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