Cell transcriptomic atlas of the non-human primate Macaca fascicularis

Lei Han; Xiaoyu Wei; Chuanyu Liu; Giacomo Volpe; Zhenkun Zhuang; Xuanxuan Zou; Zhifeng Wang; Taotao Pan; Yue Yuan; Xiao Zhang; Peng Fan; Pengcheng Guo; Yiwei Lai; Ying Lei; Xingyuan Liu; Feng Yu; Shuncheng Shangguan; Guangyao Lai; Qiuting Deng; Ya Liu; Liang Wu; Quan Shi; Hao Yu; Yunting Huang; Mengnan Cheng; Jiangshan Xu; Yang Liu; Mingyue Wang; Chunqing Wang; Yuanhang Zhang; Duo Xie; Yunzhi Yang; Yeya Yu; Huiwen Zheng; Yanrong Wei; Fubaoqian Huang; Junjie Lei; Waidong Huang; Zhiyong Zhu; Haorong Lu; Bo Wang; Xiaofeng Wei; Fengzhen Chen; Tao Yang; Wensi Du; Jing Chen; Shibo Xu; Juan An; Carl Ward; Zongren Wang; Zhong Pei; Chi Wai Wong; Xiaolei Liu; Huafeng Zhang; Mingyuan Liu; Baoming Qin; Axel Schambach; Joan Isern; Liqiang Feng; Yan Liu; Xiangyu Guo; Zhen Liu; Qiang Sun; Patrick H. Maxwell; Nick Barker; Pura Muñoz-Cánoves; Ying Gu; Jan Mulder; Mathias Uhlen; Tao Tan; Shiping Liu; Huanming Yang; Jian Wang; Yong Hou; Xun Xu; Miguel A. Esteban; Longqi Liu

doi:10.1038/s41586-022-04587-3

Cell transcriptomic atlas of the non-human primate Macaca fascicularis

Lei Han
, Xiaoyu Wei
, Chuanyu Liu
, Giacomo Volpe
, Zhenkun Zhuang
, Xuanxuan Zou
, Zhifeng Wang
, Taotao Pan
, Yue Yuan
, Xiao Zhang
, Peng Fan
, Pengcheng Guo
, Yiwei Lai
, Ying Lei
, Xingyuan Liu
, Feng Yu
, Shuncheng Shangguan
, Guangyao Lai
, Qiuting Deng
, Ya Liu

Liang Wu, Quan Shi, Hao Yu, Yunting Huang, Mengnan Cheng, Jiangshan Xu, Yang Liu, Mingyue Wang, Chunqing Wang, Yuanhang Zhang, Duo Xie, Yunzhi Yang, Yeya Yu, Huiwen Zheng, Yanrong Wei, Fubaoqian Huang, Junjie Lei, Waidong Huang, Zhiyong Zhu, Haorong Lu, Bo Wang, Xiaofeng Wei, Fengzhen Chen, Tao Yang, Wensi Du, Jing Chen, Shibo Xu, Juan An, Carl Ward, Zongren Wang, Zhong Pei, Chi Wai Wong, Xiaolei Liu, Huafeng Zhang, Mingyuan Liu, Baoming Qin, Axel Schambach, Joan Isern, Liqiang Feng, Yan Liu, Xiangyu Guo, Zhen Liu, Qiang Sun, Patrick H. Maxwell, Nick Barker, Pura Muñoz-Cánoves, Ying Gu, Jan Mulder, Mathias Uhlen, Tao Tan, Shiping Liu, Huanming Yang, Jian Wang, Yong Hou, Xun Xu, Miguel A. Esteban, Longqi Liu

Research output: Contribution to journal › Article › peer-review

147 Scopus citations

Abstract

Studying tissue composition and function in non-human primates (NHPs) is crucial to understand the nature of our own species. Here we present a large-scale cell transcriptomic atlas that encompasses over 1 million cells from 45 tissues of the adult NHP Macaca fascicularis. This dataset provides a vast annotated resource to study a species phylogenetically close to humans. To demonstrate the utility of the atlas, we have reconstructed the cell–cell interaction networks that drive Wnt signalling across the body, mapped the distribution of receptors and co-receptors for viruses causing human infectious diseases, and intersected our data with human genetic disease orthologues to establish potential clinical associations. Our M. fascicularis cell atlas constitutes an essential reference for future studies in humans and NHPs.

Original language	English
Pages (from-to)	723-731
Number of pages	9
Journal	Nature
Volume	604
Issue number	7907
DOIs	https://doi.org/10.1038/s41586-022-04587-3
State	Published - 28 Apr 2022
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/s41586-022-04587-3

Cite this

@article{55765e683f18411e91877aadc3d09283,

title = "Cell transcriptomic atlas of the non-human primate Macaca fascicularis",

abstract = "Studying tissue composition and function in non-human primates (NHPs) is crucial to understand the nature of our own species. Here we present a large-scale cell transcriptomic atlas that encompasses over 1 million cells from 45 tissues of the adult NHP Macaca fascicularis. This dataset provides a vast annotated resource to study a species phylogenetically close to humans. To demonstrate the utility of the atlas, we have reconstructed the cell–cell interaction networks that drive Wnt signalling across the body, mapped the distribution of receptors and co-receptors for viruses causing human infectious diseases, and intersected our data with human genetic disease orthologues to establish potential clinical associations. Our M. fascicularis cell atlas constitutes an essential reference for future studies in humans and NHPs.",

author = "Lei Han and Xiaoyu Wei and Chuanyu Liu and Giacomo Volpe and Zhenkun Zhuang and Xuanxuan Zou and Zhifeng Wang and Taotao Pan and Yue Yuan and Xiao Zhang and Peng Fan and Pengcheng Guo and Yiwei Lai and Ying Lei and Xingyuan Liu and Feng Yu and Shuncheng Shangguan and Guangyao Lai and Qiuting Deng and Ya Liu and Liang Wu and Quan Shi and Hao Yu and Yunting Huang and Mengnan Cheng and Jiangshan Xu and Yang Liu and Mingyue Wang and Chunqing Wang and Yuanhang Zhang and Duo Xie and Yunzhi Yang and Yeya Yu and Huiwen Zheng and Yanrong Wei and Fubaoqian Huang and Junjie Lei and Waidong Huang and Zhiyong Zhu and Haorong Lu and Bo Wang and Xiaofeng Wei and Fengzhen Chen and Tao Yang and Wensi Du and Jing Chen and Shibo Xu and Juan An and Carl Ward and Zongren Wang and Zhong Pei and Wong, \{Chi Wai\} and Xiaolei Liu and Huafeng Zhang and Mingyuan Liu and Baoming Qin and Axel Schambach and Joan Isern and Liqiang Feng and Yan Liu and Xiangyu Guo and Zhen Liu and Qiang Sun and Maxwell, \{Patrick H.\} and Nick Barker and Pura Mu{\~n}oz-C{\'a}noves and Ying Gu and Jan Mulder and Mathias Uhlen and Tao Tan and Shiping Liu and Huanming Yang and Jian Wang and Yong Hou and Xun Xu and Esteban, \{Miguel A.\} and Longqi Liu",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Nature Limited.",

year = "2022",

month = apr,

day = "28",

doi = "10.1038/s41586-022-04587-3",

language = "英语",

volume = "604",

pages = "723--731",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Research",

number = "7907",

}

Han, L, Wei, X, Liu, C, Volpe, G, Zhuang, Z, Zou, X, Wang, Z, Pan, T, Yuan, Y, Zhang, X, Fan, P, Guo, P, Lai, Y, Lei, Y, Liu, X, Yu, F, Shangguan, S, Lai, G, Deng, Q, Liu, Y, Wu, L, Shi, Q, Yu, H, Huang, Y, Cheng, M, Xu, J, Liu, Y, Wang, M, Wang, C, Zhang, Y, Xie, D, Yang, Y, Yu, Y, Zheng, H, Wei, Y, Huang, F, Lei, J, Huang, W, Zhu, Z, Lu, H, Wang, B, Wei, X, Chen, F, Yang, T, Du, W, Chen, J, Xu, S, An, J, Ward, C, Wang, Z, Pei, Z, Wong, CW, Liu, X, Zhang, H, Liu, M, Qin, B, Schambach, A, Isern, J, Feng, L, Liu, Y, Guo, X, Liu, Z, Sun, Q, Maxwell, PH, Barker, N, Muñoz-Cánoves, P, Gu, Y, Mulder, J, Uhlen, M, Tan, T, Liu, S, Yang, H, Wang, J, Hou, Y, Xu, X, Esteban, MA & Liu, L 2022, 'Cell transcriptomic atlas of the non-human primate Macaca fascicularis', Nature, vol. 604, no. 7907, pp. 723-731. https://doi.org/10.1038/s41586-022-04587-3

TY - JOUR

T1 - Cell transcriptomic atlas of the non-human primate Macaca fascicularis

AU - Han, Lei

AU - Wei, Xiaoyu

AU - Liu, Chuanyu

AU - Volpe, Giacomo

AU - Zhuang, Zhenkun

AU - Zou, Xuanxuan

AU - Wang, Zhifeng

AU - Pan, Taotao

AU - Yuan, Yue

AU - Zhang, Xiao

AU - Fan, Peng

AU - Guo, Pengcheng

AU - Lai, Yiwei

AU - Lei, Ying

AU - Liu, Xingyuan

AU - Yu, Feng

AU - Shangguan, Shuncheng

AU - Lai, Guangyao

AU - Deng, Qiuting

AU - Liu, Ya

AU - Wu, Liang

AU - Shi, Quan

AU - Yu, Hao

AU - Huang, Yunting

AU - Cheng, Mengnan

AU - Xu, Jiangshan

AU - Liu, Yang

AU - Wang, Mingyue

AU - Wang, Chunqing

AU - Zhang, Yuanhang

AU - Xie, Duo

AU - Yang, Yunzhi

AU - Yu, Yeya

AU - Zheng, Huiwen

AU - Wei, Yanrong

AU - Huang, Fubaoqian

AU - Lei, Junjie

AU - Huang, Waidong

AU - Zhu, Zhiyong

AU - Lu, Haorong

AU - Wang, Bo

AU - Wei, Xiaofeng

AU - Chen, Fengzhen

AU - Yang, Tao

AU - Du, Wensi

AU - Chen, Jing

AU - Xu, Shibo

AU - An, Juan

AU - Ward, Carl

AU - Wang, Zongren

AU - Pei, Zhong

AU - Wong, Chi Wai

AU - Liu, Xiaolei

AU - Zhang, Huafeng

AU - Liu, Mingyuan

AU - Qin, Baoming

AU - Schambach, Axel

AU - Isern, Joan

AU - Feng, Liqiang

AU - Liu, Yan

AU - Guo, Xiangyu

AU - Liu, Zhen

AU - Sun, Qiang

AU - Maxwell, Patrick H.

AU - Barker, Nick

AU - Muñoz-Cánoves, Pura

AU - Gu, Ying

AU - Mulder, Jan

AU - Uhlen, Mathias

AU - Tan, Tao

AU - Liu, Shiping

AU - Yang, Huanming

AU - Wang, Jian

AU - Hou, Yong

AU - Xu, Xun

AU - Esteban, Miguel A.

AU - Liu, Longqi

PY - 2022/4/28

Y1 - 2022/4/28

N2 - Studying tissue composition and function in non-human primates (NHPs) is crucial to understand the nature of our own species. Here we present a large-scale cell transcriptomic atlas that encompasses over 1 million cells from 45 tissues of the adult NHP Macaca fascicularis. This dataset provides a vast annotated resource to study a species phylogenetically close to humans. To demonstrate the utility of the atlas, we have reconstructed the cell–cell interaction networks that drive Wnt signalling across the body, mapped the distribution of receptors and co-receptors for viruses causing human infectious diseases, and intersected our data with human genetic disease orthologues to establish potential clinical associations. Our M. fascicularis cell atlas constitutes an essential reference for future studies in humans and NHPs.

AB - Studying tissue composition and function in non-human primates (NHPs) is crucial to understand the nature of our own species. Here we present a large-scale cell transcriptomic atlas that encompasses over 1 million cells from 45 tissues of the adult NHP Macaca fascicularis. This dataset provides a vast annotated resource to study a species phylogenetically close to humans. To demonstrate the utility of the atlas, we have reconstructed the cell–cell interaction networks that drive Wnt signalling across the body, mapped the distribution of receptors and co-receptors for viruses causing human infectious diseases, and intersected our data with human genetic disease orthologues to establish potential clinical associations. Our M. fascicularis cell atlas constitutes an essential reference for future studies in humans and NHPs.

UR - https://www.scopus.com/pages/publications/85127941630

U2 - 10.1038/s41586-022-04587-3

DO - 10.1038/s41586-022-04587-3

M3 - 文章

C2 - 35418686

AN - SCOPUS:85127941630

SN - 0028-0836

VL - 604

SP - 723

EP - 731

JO - Nature

JF - Nature

IS - 7907

ER -

Cell transcriptomic atlas of the non-human primate Macaca fascicularis

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this