Cancer Physical Hallmarks as New Targets for Improved Immunotherapy

Hui Guo; Tian Zhang; Yang Yu; Feng Xu

doi:10.1016/j.tcb.2021.03.011

Cancer Physical Hallmarks as New Targets for Improved Immunotherapy

Hui Guo
, Tian Zhang
, Yang Yu
, Feng Xu

The First Affiliated Hospital of Xi’an Jiaotong University
Xi'an Jiaotong University

Research output: Contribution to journal › Short survey › peer-review

28 Scopus citations

Abstract

A low response rate is the major challenge for existing cancer immunotherapies. Physical cues in the tumor microenvironment (TME) have been recognized as new hallmarks of cancer, which may synergistically contribute to low immunotherapy response. Recent evidence indicates that the physical hallmarks of cancer hold great potential as new targets for improved immunotherapy.

Original language	English
Pages (from-to)	520-524
Number of pages	5
Journal	Trends in Cell Biology
Volume	31
Issue number	7
DOIs	https://doi.org/10.1016/j.tcb.2021.03.011
State	Published - Jul 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cancer immunotherapy
immune-engineering
immunophenotype
mechano-nanomedicine
physical microenvironment

Access to Document

10.1016/j.tcb.2021.03.011

Cite this

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title = "Cancer Physical Hallmarks as New Targets for Improved Immunotherapy",

abstract = "A low response rate is the major challenge for existing cancer immunotherapies. Physical cues in the tumor microenvironment (TME) have been recognized as new hallmarks of cancer, which may synergistically contribute to low immunotherapy response. Recent evidence indicates that the physical hallmarks of cancer hold great potential as new targets for improved immunotherapy.",

keywords = "cancer immunotherapy, immune-engineering, immunophenotype, mechano-nanomedicine, physical microenvironment",

author = "Hui Guo and Tian Zhang and Yang Yu and Feng Xu",

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AU - Guo, Hui

AU - Zhang, Tian

AU - Yu, Yang

AU - Xu, Feng

PY - 2021/7

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N2 - A low response rate is the major challenge for existing cancer immunotherapies. Physical cues in the tumor microenvironment (TME) have been recognized as new hallmarks of cancer, which may synergistically contribute to low immunotherapy response. Recent evidence indicates that the physical hallmarks of cancer hold great potential as new targets for improved immunotherapy.

AB - A low response rate is the major challenge for existing cancer immunotherapies. Physical cues in the tumor microenvironment (TME) have been recognized as new hallmarks of cancer, which may synergistically contribute to low immunotherapy response. Recent evidence indicates that the physical hallmarks of cancer hold great potential as new targets for improved immunotherapy.

KW - cancer immunotherapy

KW - immune-engineering

KW - immunophenotype

KW - mechano-nanomedicine

KW - physical microenvironment

UR - https://www.scopus.com/pages/publications/85107098132

U2 - 10.1016/j.tcb.2021.03.011

DO - 10.1016/j.tcb.2021.03.011

M3 - 短篇评述

C2 - 33926772

AN - SCOPUS:85107098132

SN - 0962-8924

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SP - 520

EP - 524

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 7

ER -

Cancer Physical Hallmarks as New Targets for Improved Immunotherapy

Abstract

UN SDGs

Keywords

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