TY - JOUR
T1 - Ca substitution of Sr in Sr-doped TiO2 nanotube film on Ti surface for enhanced osteogenic activity
AU - Zhang, Yanni
AU - Wang, Kun
AU - Song, Yang
AU - Feng, Enping
AU - Dong, Kai
AU - Han, Yong
AU - Lu, Tingli
N1 - Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2020/10/30
Y1 - 2020/10/30
N2 - The intrinsic bioinertness of titanium (Ti) as an endosseous implant is still a grand challenge to achieve faster and stable implant osseointegration. A multitude of TiO2 nanotubes loaded with Sr have been developed to improve the biological performance of Ti implants, which, however, remained limited. In this study, a Sr&Ca co-doped TiO2 nanotube film (M-SrCaNT) was fabricated using a modified anodization, following by hydrothermal treatment. Results showed that half amount of Sr in Sr-doped TiO2 nanotubes (M-SrNT) could be substituted by Ca to generate M-SrCaNT, without changing the nanotubular structure. Interestingly, M-SrNT and M-SrCaNT revealed similar micro/nano-topographic surface characteristics. The production of osteogenic signals by TiO2 nanotubes (M-NT) was obviously limited as compared with Ti, which could be could be compensated by M-SrNT with superior surface micro/nano-topography and bioactive element Sr. Furthermore, as compared with M-SrNT, M-SrCaNT with the co-presence of Sr&Ca exhibited much more efficient in enhancing the attachment, proliferation and osteogenic activities (gene expressions, extracellular matrix synthesis and mineralization) of MC3T3-E1 cells. This study provided an outstanding biomimetic surface constructed by co-incorporating Sr&Ca into TiO2 nanotubular structure on Ti implant. It represented a promising approach for rapid formation of strong and long-lasting bond between implant-bone interface.
AB - The intrinsic bioinertness of titanium (Ti) as an endosseous implant is still a grand challenge to achieve faster and stable implant osseointegration. A multitude of TiO2 nanotubes loaded with Sr have been developed to improve the biological performance of Ti implants, which, however, remained limited. In this study, a Sr&Ca co-doped TiO2 nanotube film (M-SrCaNT) was fabricated using a modified anodization, following by hydrothermal treatment. Results showed that half amount of Sr in Sr-doped TiO2 nanotubes (M-SrNT) could be substituted by Ca to generate M-SrCaNT, without changing the nanotubular structure. Interestingly, M-SrNT and M-SrCaNT revealed similar micro/nano-topographic surface characteristics. The production of osteogenic signals by TiO2 nanotubes (M-NT) was obviously limited as compared with Ti, which could be could be compensated by M-SrNT with superior surface micro/nano-topography and bioactive element Sr. Furthermore, as compared with M-SrNT, M-SrCaNT with the co-presence of Sr&Ca exhibited much more efficient in enhancing the attachment, proliferation and osteogenic activities (gene expressions, extracellular matrix synthesis and mineralization) of MC3T3-E1 cells. This study provided an outstanding biomimetic surface constructed by co-incorporating Sr&Ca into TiO2 nanotubular structure on Ti implant. It represented a promising approach for rapid formation of strong and long-lasting bond between implant-bone interface.
KW - Calcium
KW - Co-doping
KW - Osteogenic differentiation
KW - Strontium
KW - TiO nanotubes
UR - https://www.scopus.com/pages/publications/85086893246
U2 - 10.1016/j.apsusc.2020.147055
DO - 10.1016/j.apsusc.2020.147055
M3 - 文章
AN - SCOPUS:85086893246
SN - 0169-4332
VL - 528
JO - Applied Surface Science
JF - Applied Surface Science
M1 - 147055
ER -