Brushlike Cationic Polymers with Low Charge Density for Gene Delivery

Jonathan O'Keeffe Ahern; A. Sigen; Dezhong Zhou; Yongsheng Gao; Jing Lyu; Zhao Meng; Lara Cutlar; Luca Pierucci; Wenxin Wang

doi:10.1021/acs.biomac.7b01267

Brushlike Cationic Polymers with Low Charge Density for Gene Delivery

Jonathan O'Keeffe Ahern
, A. Sigen
, Dezhong Zhou
, Yongsheng Gao
, Jing Lyu
, Zhao Meng
, Lara Cutlar
, Luca Pierucci
, Wenxin Wang

University College Dublin

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Using a combined synthesis approach comprising reversible addition-fragmentation transfer polymerization and ring opening reaction, a series of poly glycidyl methacrylate (polyGMA) polymers were designed and synthesized for gene delivery. These polymers characterized by low cationic charge respective to established gene delivery vectors such as PEI were studied to further elucidate the key structure-activity parameters that mediate efficient and biocompatible gene delivery. Compared to PEI, these brushlike polymers facilitated markedly improved safety and gene delivery efficiency.

Original language	English
Pages (from-to)	1410-1415
Number of pages	6
Journal	Biomacromolecules
Volume	19
Issue number	5
DOIs	https://doi.org/10.1021/acs.biomac.7b01267
State	Published - 14 May 2018
Externally published	Yes

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title = "Brushlike Cationic Polymers with Low Charge Density for Gene Delivery",

abstract = "Using a combined synthesis approach comprising reversible addition-fragmentation transfer polymerization and ring opening reaction, a series of poly glycidyl methacrylate (polyGMA) polymers were designed and synthesized for gene delivery. These polymers characterized by low cationic charge respective to established gene delivery vectors such as PEI were studied to further elucidate the key structure-activity parameters that mediate efficient and biocompatible gene delivery. Compared to PEI, these brushlike polymers facilitated markedly improved safety and gene delivery efficiency.",

author = "\{O'Keeffe Ahern\}, Jonathan and A. Sigen and Dezhong Zhou and Yongsheng Gao and Jing Lyu and Zhao Meng and Lara Cutlar and Luca Pierucci and Wenxin Wang",

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T1 - Brushlike Cationic Polymers with Low Charge Density for Gene Delivery

AU - O'Keeffe Ahern, Jonathan

AU - Sigen, A.

AU - Zhou, Dezhong

AU - Gao, Yongsheng

AU - Lyu, Jing

AU - Meng, Zhao

AU - Cutlar, Lara

AU - Pierucci, Luca

AU - Wang, Wenxin

PY - 2018/5/14

Y1 - 2018/5/14

N2 - Using a combined synthesis approach comprising reversible addition-fragmentation transfer polymerization and ring opening reaction, a series of poly glycidyl methacrylate (polyGMA) polymers were designed and synthesized for gene delivery. These polymers characterized by low cationic charge respective to established gene delivery vectors such as PEI were studied to further elucidate the key structure-activity parameters that mediate efficient and biocompatible gene delivery. Compared to PEI, these brushlike polymers facilitated markedly improved safety and gene delivery efficiency.

AB - Using a combined synthesis approach comprising reversible addition-fragmentation transfer polymerization and ring opening reaction, a series of poly glycidyl methacrylate (polyGMA) polymers were designed and synthesized for gene delivery. These polymers characterized by low cationic charge respective to established gene delivery vectors such as PEI were studied to further elucidate the key structure-activity parameters that mediate efficient and biocompatible gene delivery. Compared to PEI, these brushlike polymers facilitated markedly improved safety and gene delivery efficiency.

UR - https://www.scopus.com/pages/publications/85046998096

U2 - 10.1021/acs.biomac.7b01267

DO - 10.1021/acs.biomac.7b01267

M3 - 文章

C2 - 29125281

AN - SCOPUS:85046998096

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SP - 1410

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JO - Biomacromolecules

JF - Biomacromolecules

IS - 5

ER -

Brushlike Cationic Polymers with Low Charge Density for Gene Delivery

Abstract

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