Boronate based fluorescence (ESIPT) probe for peroxynitrite

Adam C. Sedgwick; Xiaolong Sun; Gyoungmi Kim; Juyoung Yoon; Steven D. Bull; Tony D. James

doi:10.1039/c6cc06829d

Boronate based fluorescence (ESIPT) probe for peroxynitrite

Adam C. Sedgwick
, Xiaolong Sun
, Gyoungmi Kim
, Juyoung Yoon
, Steven D. Bull
, Tony D. James

School of Life Science and Technology (SLST)

Research output: Contribution to journal › Article › peer-review

117 Scopus citations

Abstract

A simple probe for the detection of peroxynitrite was developed incorporating a benzyl boronic ester "protecting" unit. The "protecting" unit of the probe is removed by peroxynitrite to "turn-on" ESIPT fluorescence (4.5 fold enhancement). Furthermore, the probe was cell permeable and was used in cell imaging experiments showing an off-on response towards peroxynitrite, in HeLa and RAW 264.7 cells.

Original language	English
Pages (from-to)	12350-12352
Number of pages	3
Journal	Chemical Communications
Volume	52
Issue number	83
DOIs	https://doi.org/10.1039/c6cc06829d
State	Published - 2016

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10.1039/c6cc06829d

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title = "Boronate based fluorescence (ESIPT) probe for peroxynitrite",

abstract = "A simple probe for the detection of peroxynitrite was developed incorporating a benzyl boronic ester {"}protecting{"} unit. The {"}protecting{"} unit of the probe is removed by peroxynitrite to {"}turn-on{"} ESIPT fluorescence (4.5 fold enhancement). Furthermore, the probe was cell permeable and was used in cell imaging experiments showing an off-on response towards peroxynitrite, in HeLa and RAW 264.7 cells.",

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AU - Sedgwick, Adam C.

AU - Sun, Xiaolong

AU - Kim, Gyoungmi

AU - Yoon, Juyoung

AU - Bull, Steven D.

AU - James, Tony D.

PY - 2016

Y1 - 2016

N2 - A simple probe for the detection of peroxynitrite was developed incorporating a benzyl boronic ester "protecting" unit. The "protecting" unit of the probe is removed by peroxynitrite to "turn-on" ESIPT fluorescence (4.5 fold enhancement). Furthermore, the probe was cell permeable and was used in cell imaging experiments showing an off-on response towards peroxynitrite, in HeLa and RAW 264.7 cells.

AB - A simple probe for the detection of peroxynitrite was developed incorporating a benzyl boronic ester "protecting" unit. The "protecting" unit of the probe is removed by peroxynitrite to "turn-on" ESIPT fluorescence (4.5 fold enhancement). Furthermore, the probe was cell permeable and was used in cell imaging experiments showing an off-on response towards peroxynitrite, in HeLa and RAW 264.7 cells.

UR - https://www.scopus.com/pages/publications/84991489171

U2 - 10.1039/c6cc06829d

DO - 10.1039/c6cc06829d

M3 - 文章

AN - SCOPUS:84991489171

SN - 1359-7345

VL - 52

SP - 12350

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JO - Chemical Communications

JF - Chemical Communications

IS - 83

ER -

Boronate based fluorescence (ESIPT) probe for peroxynitrite

Abstract

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