Biomechanical properties of epithelial mesenchymal transition in idiopathic pulmonary fibrosis

  • Mingyan Li
  • , Meihao Sun
  • , Yuanbo Jia
  • , Hui Ren
  • , Han Liu

Research output: Contribution to journalArticlepeer-review

Abstract

特发性肺纤维化(IPF)是一种进行性瘢痕形成的疾病,死亡率高,已引起广泛关注。上皮间质转化(EMT)是肺纤维化进程中重要的一环,而肺组织生物力学特性的变化对其有重要影响。本文总结了近年IPF-EMT中肺组织生物力学微环境的变化规律,并对肺纤维化中力学微环境的改变对EMT进程的影响、力学因素对EMT肺泡上皮细胞行为的影响和EMT中生物力学信号的传导进行了系统综述,以期为IPF的防治研究提供新的参考。.

Original languageEnglish
Pages (from-to)632-637
Number of pages6
JournalSheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi
Volume40
Issue number4
DOIs
StatePublished - 25 Aug 2023

Keywords

  • Biomechanical microenvironment
  • Biomechanical receptors
  • Matrix stiffness
  • Mechanical stretch
  • Pulmonary fibrosis

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