Abstract
Aim: To develop a new type of big-animal model of big-segmental defect of bone used in tissue engineering to provide a basis for tissue engineering research. Methods: (1) One wet ulnar and radius specimen in adult dogs was scanned by CT, and then processed by software to build and restrain the finite element model, and the relationship between stress-strain and torque-twisting angle was computed with boundary condition pressed. (2) The defect models of middle-segmental and big-segmental bone of radius were prepared from 24 ulnar-radius specimens of adult male dogs, and were fixated respectively and randomly with three methods and control group, the anti-axial compression, anti-tension and anti-torsion intensity were compared. Results: (1) The finite element analysis(FEA) indicated that comparing the four holes designed-panel(PA) with the bracket, the panel provided a more similar stress distribution as the normal and produced lower stress concentration compared with the bracket. (2) The mechanical experiment indicated that the strain value of each group was positively correlated with loads, and the newly designed internal fixation panel was better than that of AO four holes panel and one-side external fixation bracket of bracket in all of axial compression, tension and torsion abilities. Conclusion: The animal model of tissue engineering has superiority in anti-axial compression, anti-tension and anti-torsion with a reasonable mechanical structure.
| Original language | English |
|---|---|
| Pages (from-to) | 7130-7132 |
| Number of pages | 3 |
| Journal | Chinese Journal of Clinical Rehabilitation |
| Volume | 8 |
| Issue number | 32 |
| State | Published - Nov 2004 |