TY - JOUR
T1 - Biological Imaging and Sensing with Multiresponsive Microgels
AU - Zhang, Qiang Matthew
AU - Wang, Wenda
AU - Su, Ya Qiong
AU - Hensen, Emiel J.M.
AU - Serpe, Michael J.
N1 - Publisher Copyright:
© 2015 American Chemical Society.
PY - 2016/1/12
Y1 - 2016/1/12
N2 - Multiresponsive spiropyran-modified poly(N-isopropylacrylamide)-based microgels were synthesized and their response to temperature; UV, visible, and near-infrared radiation; pH; and Cu2+ was investigated. The responses were a result of the spiropyran groups undergoing a reversible isomerization/reaction from a neutral to a charged form. The isomerization process was investigated via experiment and theory. The two-photon excited fluorescence of the spiropyran-modified microgels was also characterized, and their ability to be used to image live cells was determined. Finally, optical devices (etalons) were fabricated using the spiropyran-modified microgels, and the ability of the devices to change color in response to the above-mentioned stimuli was also investigated. We found that the microgel's responsivity was retained in the etalon, which yielded color tunable devices and sensors. This investigation illustrates the versatility of pNIPAm-based microgels and microgel-based etalons and showcases the clear utility of such devices for remote actuation, color tunable optics, sensing, and remotely triggered drug delivery systems.
AB - Multiresponsive spiropyran-modified poly(N-isopropylacrylamide)-based microgels were synthesized and their response to temperature; UV, visible, and near-infrared radiation; pH; and Cu2+ was investigated. The responses were a result of the spiropyran groups undergoing a reversible isomerization/reaction from a neutral to a charged form. The isomerization process was investigated via experiment and theory. The two-photon excited fluorescence of the spiropyran-modified microgels was also characterized, and their ability to be used to image live cells was determined. Finally, optical devices (etalons) were fabricated using the spiropyran-modified microgels, and the ability of the devices to change color in response to the above-mentioned stimuli was also investigated. We found that the microgel's responsivity was retained in the etalon, which yielded color tunable devices and sensors. This investigation illustrates the versatility of pNIPAm-based microgels and microgel-based etalons and showcases the clear utility of such devices for remote actuation, color tunable optics, sensing, and remotely triggered drug delivery systems.
UR - https://www.scopus.com/pages/publications/84954456646
U2 - 10.1021/acs.chemmater.5b04028
DO - 10.1021/acs.chemmater.5b04028
M3 - 文章
AN - SCOPUS:84954456646
SN - 0897-4756
VL - 28
SP - 259
EP - 265
JO - Chemistry of Materials
JF - Chemistry of Materials
IS - 1
ER -