Biodegradable Highly Branched Poly(β-Amino Ester)s for Targeted Cancer Cell Gene Transfection

Shuai Liu; Yongsheng Gao; A. Sigen; Dezhong Zhou; Udo Greiser; Tianying Guo; Rui Guo; Wenxin Wang

doi:10.1021/acsbiomaterials.6b00503

Biodegradable Highly Branched Poly(β-Amino Ester)s for Targeted Cancer Cell Gene Transfection

Shuai Liu
, Yongsheng Gao
, A. Sigen
, Dezhong Zhou
, Udo Greiser
, Tianying Guo
, Rui Guo
, Wenxin Wang

University College Dublin
Nankai University
Jinan University

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

To enhance the gene transfection efficiency to targeted cells while reducing the side effects to untargeted cells is of great significance for clinical gene therapy. Here, biodegradable highly branched poly(β-amino ester)s (HPAESS) are synthesized and functionalized with folate (HPAESS-FA) and lactobionic acid (HPAESS-Lac) for targeted cancer cell gene transfection. Results show that because of the triggered degradability of the vector and enhanced receptor-mediated cellular uptake of polyplexes, the HPAESS-FA and HPAESS-Lac exhibit superior gene transfection capability in specific cancer cells with negligible cytotoxicity, pointing to their promise as targeted vectors for efficient cancer gene therapy.

Original language	English
Pages (from-to)	1283-1286
Number of pages	4
Journal	ACS Biomaterials Science and Engineering
Volume	3
Issue number	7
DOIs	https://doi.org/10.1021/acsbiomaterials.6b00503
State	Published - 10 Jul 2017
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

biodegradable
cancer cells
gene transfection
highly branched poly(β-amino ester)s
targeting

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10.1021/acsbiomaterials.6b00503

Cite this

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title = "Biodegradable Highly Branched Poly(β-Amino Ester)s for Targeted Cancer Cell Gene Transfection",

abstract = "To enhance the gene transfection efficiency to targeted cells while reducing the side effects to untargeted cells is of great significance for clinical gene therapy. Here, biodegradable highly branched poly(β-amino ester)s (HPAESS) are synthesized and functionalized with folate (HPAESS-FA) and lactobionic acid (HPAESS-Lac) for targeted cancer cell gene transfection. Results show that because of the triggered degradability of the vector and enhanced receptor-mediated cellular uptake of polyplexes, the HPAESS-FA and HPAESS-Lac exhibit superior gene transfection capability in specific cancer cells with negligible cytotoxicity, pointing to their promise as targeted vectors for efficient cancer gene therapy.",

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author = "Shuai Liu and Yongsheng Gao and A. Sigen and Dezhong Zhou and Udo Greiser and Tianying Guo and Rui Guo and Wenxin Wang",

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doi = "10.1021/acsbiomaterials.6b00503",

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T1 - Biodegradable Highly Branched Poly(β-Amino Ester)s for Targeted Cancer Cell Gene Transfection

AU - Liu, Shuai

AU - Gao, Yongsheng

AU - Sigen, A.

AU - Zhou, Dezhong

AU - Greiser, Udo

AU - Guo, Tianying

AU - Guo, Rui

AU - Wang, Wenxin

PY - 2017/7/10

Y1 - 2017/7/10

N2 - To enhance the gene transfection efficiency to targeted cells while reducing the side effects to untargeted cells is of great significance for clinical gene therapy. Here, biodegradable highly branched poly(β-amino ester)s (HPAESS) are synthesized and functionalized with folate (HPAESS-FA) and lactobionic acid (HPAESS-Lac) for targeted cancer cell gene transfection. Results show that because of the triggered degradability of the vector and enhanced receptor-mediated cellular uptake of polyplexes, the HPAESS-FA and HPAESS-Lac exhibit superior gene transfection capability in specific cancer cells with negligible cytotoxicity, pointing to their promise as targeted vectors for efficient cancer gene therapy.

AB - To enhance the gene transfection efficiency to targeted cells while reducing the side effects to untargeted cells is of great significance for clinical gene therapy. Here, biodegradable highly branched poly(β-amino ester)s (HPAESS) are synthesized and functionalized with folate (HPAESS-FA) and lactobionic acid (HPAESS-Lac) for targeted cancer cell gene transfection. Results show that because of the triggered degradability of the vector and enhanced receptor-mediated cellular uptake of polyplexes, the HPAESS-FA and HPAESS-Lac exhibit superior gene transfection capability in specific cancer cells with negligible cytotoxicity, pointing to their promise as targeted vectors for efficient cancer gene therapy.

KW - biodegradable

KW - cancer cells

KW - gene transfection

KW - highly branched poly(β-amino ester)s

KW - targeting

UR - https://www.scopus.com/pages/publications/85022206815

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DO - 10.1021/acsbiomaterials.6b00503

M3 - 文章

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JO - ACS Biomaterials Science and Engineering

JF - ACS Biomaterials Science and Engineering

IS - 7

ER -

Biodegradable Highly Branched Poly(β-Amino Ester)s for Targeted Cancer Cell Gene Transfection

Abstract

UN SDGs

Keywords

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