Bioactive glass ions hydrogels with antiinflammation antioxidant capacity for treating inflammation-related diseases

Inflammation-related infected wound and rheumatoid arthritis (RA) are still the challenge in biomedical filed. Bioactive molecules and materials are showing much interest in treating inflammation-related diseases. Herein, we report an antiinflammatory antioxidant angiogenetic bioactive ions-based scaffold based on the bioactive nanoglass for treating methicillin-resistant staphylococcus aureus (MRSA) infected wound and RA. It was found that the bioactive nanoglass ions (BNGI) with 3 × and 6 × dilution demonstrated the significant anti-inflammation ability (the inhibition of Tnf-α and IL1β), macrophage polarization function (the decrease of CD86⁺ cells), antioxidant and angiogenic capacities (the increased node number, branching length and CD31 expression). 1 × diluted BNGI-derived Pluronic F127 and gelatin methacryloyl hydrogels could significantly enhance the MRSA-infected wound healing and attenuate the RA progression through stimulating the secretion of antiinflammation exosomes from macrophage (3-fold upregulation compared with 3M^TM dressing) and proper angiogenesis based on the important role of silicon (about 150 mg/L in vivo and 25.4 to 48.1 mg/L in vitro) in BNGI. Our findings revealed the therapeutic function and potential mechanism of BNGI in inflammatory diseases and tissue engineering.