Betulinic Acid and its Derivatives as Potential Antitumor Agents

Dong Mei Zhang; Hong Gui Xu; Lei Wang; Ying Jie Li; Ping Hua Sun; Xiao Ming Wu; Guang Ji Wang; Wei Min Chen; Wen Cai Ye

doi:10.1002/med.21353

Betulinic Acid and its Derivatives as Potential Antitumor Agents

Dong Mei Zhang
, Hong Gui Xu
, Lei Wang
, Ying Jie Li
, Ping Hua Sun
, Xiao Ming Wu
, Guang Ji Wang
, Wei Min Chen
, Wen Cai Ye

Research output: Contribution to journal › Article › peer-review

187 Scopus citations

Abstract

Betulinic acid (BA) is a lupane-type pentacyclic triterpene, distributed ubiquitously throughout the plant kingdom. BA and its derivatives demonstrate multiple bioactivities, particularly an antitumor effect. This review critically describes the recent research on isolation, synthesis, and derivatization of BA and its natural analogs betulin and 23-hydroxybetulinic acid. The subsequent part of the review focuses on the current knowledge of antitumor properties, combination treatments, and pharmacological mechanisms of these compounds. A 3D-QSAR analysis of 62 BA derivatives against human ovarian cancer A2780 is also included to provide information concerning the structure-cytotoxicity relationships of these compounds.

Original language	English
Pages (from-to)	1127-1155
Number of pages	29
Journal	Medicinal Research Reviews
Volume	35
Issue number	6
DOIs	https://doi.org/10.1002/med.21353
State	Published - Nov 2015
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Antitumor effect
Betulinic acid
Derivatives
Structure-cytotoxicity relationship

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10.1002/med.21353

Cite this

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title = "Betulinic Acid and its Derivatives as Potential Antitumor Agents",

abstract = "Betulinic acid (BA) is a lupane-type pentacyclic triterpene, distributed ubiquitously throughout the plant kingdom. BA and its derivatives demonstrate multiple bioactivities, particularly an antitumor effect. This review critically describes the recent research on isolation, synthesis, and derivatization of BA and its natural analogs betulin and 23-hydroxybetulinic acid. The subsequent part of the review focuses on the current knowledge of antitumor properties, combination treatments, and pharmacological mechanisms of these compounds. A 3D-QSAR analysis of 62 BA derivatives against human ovarian cancer A2780 is also included to provide information concerning the structure-cytotoxicity relationships of these compounds.",

keywords = "Antitumor effect, Betulinic acid, Derivatives, Structure-cytotoxicity relationship",

author = "Zhang, \{Dong Mei\} and Xu, \{Hong Gui\} and Lei Wang and Li, \{Ying Jie\} and Sun, \{Ping Hua\} and Wu, \{Xiao Ming\} and Wang, \{Guang Ji\} and Chen, \{Wei Min\} and Ye, \{Wen Cai\}",

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year = "2015",

month = nov,

doi = "10.1002/med.21353",

language = "英语",

volume = "35",

pages = "1127--1155",

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}

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T1 - Betulinic Acid and its Derivatives as Potential Antitumor Agents

AU - Zhang, Dong Mei

AU - Xu, Hong Gui

AU - Wang, Lei

AU - Li, Ying Jie

AU - Sun, Ping Hua

AU - Wu, Xiao Ming

AU - Wang, Guang Ji

AU - Chen, Wei Min

AU - Ye, Wen Cai

PY - 2015/11

Y1 - 2015/11

N2 - Betulinic acid (BA) is a lupane-type pentacyclic triterpene, distributed ubiquitously throughout the plant kingdom. BA and its derivatives demonstrate multiple bioactivities, particularly an antitumor effect. This review critically describes the recent research on isolation, synthesis, and derivatization of BA and its natural analogs betulin and 23-hydroxybetulinic acid. The subsequent part of the review focuses on the current knowledge of antitumor properties, combination treatments, and pharmacological mechanisms of these compounds. A 3D-QSAR analysis of 62 BA derivatives against human ovarian cancer A2780 is also included to provide information concerning the structure-cytotoxicity relationships of these compounds.

AB - Betulinic acid (BA) is a lupane-type pentacyclic triterpene, distributed ubiquitously throughout the plant kingdom. BA and its derivatives demonstrate multiple bioactivities, particularly an antitumor effect. This review critically describes the recent research on isolation, synthesis, and derivatization of BA and its natural analogs betulin and 23-hydroxybetulinic acid. The subsequent part of the review focuses on the current knowledge of antitumor properties, combination treatments, and pharmacological mechanisms of these compounds. A 3D-QSAR analysis of 62 BA derivatives against human ovarian cancer A2780 is also included to provide information concerning the structure-cytotoxicity relationships of these compounds.

KW - Antitumor effect

KW - Betulinic acid

KW - Derivatives

KW - Structure-cytotoxicity relationship

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U2 - 10.1002/med.21353

DO - 10.1002/med.21353

M3 - 文章

C2 - 26032847

AN - SCOPUS:84943581682

SN - 0198-6325

VL - 35

SP - 1127

EP - 1155

JO - Medicinal Research Reviews

JF - Medicinal Research Reviews

IS - 6

ER -

Betulinic Acid and its Derivatives as Potential Antitumor Agents

Abstract

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Keywords

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