Atmospheric-pressure plasma interaction with Thymidine in aqueous solution

The cold atmospheric-pressure plasmas have great application prospects in the fields of biomedicine, such as killing virus, sterilization, cancer cells ablation, and surface treatment of organism tissue, etc. Some reports have indicated that the cold atmospheric-pressure plasmas will modify the genetic material (RNA and DNA) in organism tissue. Thymine is one of the components of genetic material. In this paper, in order to study the effect of plasma on genetic Thymine process, Thymine and Thymidine in the aqueous solution were treated by plasma. In order to avoid the effect of air on experiments, a new discharge device was designed to generate large-area plasma in aqueous media. The results show that, after different gas plasma processing, Thymidine decomposes for thymine; After air plasma and oxygen plasma treatment, Thymidine can produce two new decomposition products: Thymine +OH and Thymidine +OH. The study of DNA degration caused by plasma has certain instruction function in biomedicine.