Astragalus polysaccharides driven stretchable nanofibrous membrane wound dressing for joint wound healing

Jinpeng Wen; Datao Hu; Ruisi Wang; Kailai Liu; Yunhe Zheng; Jiangchuan He; Xi Chen; Yuchen Zhang; Xinxin Zhao; Yizhuo Bu; Botao Song; Lin Wang; Ke Wang

doi:10.1016/j.ijbiomac.2023.125557

Astragalus polysaccharides driven stretchable nanofibrous membrane wound dressing for joint wound healing

Jinpeng Wen
, Datao Hu
, Ruisi Wang
, Kailai Liu
, Yunhe Zheng
, Jiangchuan He
, Xi Chen
, Yuchen Zhang
, Xinxin Zhao
, Yizhuo Bu
, Botao Song
, Lin Wang
, Ke Wang

Health Science Center

Xi'an Jiaotong University
Shenyang Pharmaceutical University
Air Force Medical University
Northwest University China
Northwest Agriculture and Forestry University

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Joint wound dressings are currently significantly limited in their clinical applications due to their inferior mechanical properties and single therapeutic effect. Therefore, it is imperative to develop a versatile joint wound dressing that integrates adequate stretchability, desirable biocompatibility, and multiple biological effects into one system. We implemented the electrospinning technique in this study to fabricate a novel nanofibrous membrane (NFM) composed of gelatin (GEL) and astragalus polysaccharides (APS), termed GEL/APS NFM. The selection of GEL and APS confers excellent biocompatibility to GEL/APS NFM. Furthermore, the optimally proportioned GEL/APS NFM exhibits satisfactory stretchability and desirable wound healing efficiency. Furthermore, released APS can exert anti-inflammatory, procollagen deposition, and proangiogenic effects to accelerate epithelial tissue, enhancing joint wound healing. In summary, GEL/APS NFM offers a convenient and effective approach to promoting rapid joint wound healing, providing a novel approach to joint wound care.

Original language	English
Article number	125557
Journal	International Journal of Biological Macromolecules
Volume	248
DOIs	https://doi.org/10.1016/j.ijbiomac.2023.125557
State	Published - 1 Sep 2023

Keywords

Anti-inflammatory
Collagen deposition
Electrospinning
Joint wound management
Nanofibrous membranes

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10.1016/j.ijbiomac.2023.125557

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title = "Astragalus polysaccharides driven stretchable nanofibrous membrane wound dressing for joint wound healing",

abstract = "Joint wound dressings are currently significantly limited in their clinical applications due to their inferior mechanical properties and single therapeutic effect. Therefore, it is imperative to develop a versatile joint wound dressing that integrates adequate stretchability, desirable biocompatibility, and multiple biological effects into one system. We implemented the electrospinning technique in this study to fabricate a novel nanofibrous membrane (NFM) composed of gelatin (GEL) and astragalus polysaccharides (APS), termed GEL/APS NFM. The selection of GEL and APS confers excellent biocompatibility to GEL/APS NFM. Furthermore, the optimally proportioned GEL/APS NFM exhibits satisfactory stretchability and desirable wound healing efficiency. Furthermore, released APS can exert anti-inflammatory, procollagen deposition, and proangiogenic effects to accelerate epithelial tissue, enhancing joint wound healing. In summary, GEL/APS NFM offers a convenient and effective approach to promoting rapid joint wound healing, providing a novel approach to joint wound care.",

keywords = "Anti-inflammatory, Collagen deposition, Electrospinning, Joint wound management, Nanofibrous membranes",

author = "Jinpeng Wen and Datao Hu and Ruisi Wang and Kailai Liu and Yunhe Zheng and Jiangchuan He and Xi Chen and Yuchen Zhang and Xinxin Zhao and Yizhuo Bu and Botao Song and Lin Wang and Ke Wang",

note = "Publisher Copyright: {\textcopyright} 2023",

year = "2023",

month = sep,

day = "1",

doi = "10.1016/j.ijbiomac.2023.125557",

language = "英语",

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TY - JOUR

T1 - Astragalus polysaccharides driven stretchable nanofibrous membrane wound dressing for joint wound healing

AU - Wen, Jinpeng

AU - Hu, Datao

AU - Wang, Ruisi

AU - Liu, Kailai

AU - Zheng, Yunhe

AU - He, Jiangchuan

AU - Chen, Xi

AU - Zhang, Yuchen

AU - Zhao, Xinxin

AU - Bu, Yizhuo

AU - Song, Botao

AU - Wang, Lin

AU - Wang, Ke

PY - 2023/9/1

Y1 - 2023/9/1

N2 - Joint wound dressings are currently significantly limited in their clinical applications due to their inferior mechanical properties and single therapeutic effect. Therefore, it is imperative to develop a versatile joint wound dressing that integrates adequate stretchability, desirable biocompatibility, and multiple biological effects into one system. We implemented the electrospinning technique in this study to fabricate a novel nanofibrous membrane (NFM) composed of gelatin (GEL) and astragalus polysaccharides (APS), termed GEL/APS NFM. The selection of GEL and APS confers excellent biocompatibility to GEL/APS NFM. Furthermore, the optimally proportioned GEL/APS NFM exhibits satisfactory stretchability and desirable wound healing efficiency. Furthermore, released APS can exert anti-inflammatory, procollagen deposition, and proangiogenic effects to accelerate epithelial tissue, enhancing joint wound healing. In summary, GEL/APS NFM offers a convenient and effective approach to promoting rapid joint wound healing, providing a novel approach to joint wound care.

AB - Joint wound dressings are currently significantly limited in their clinical applications due to their inferior mechanical properties and single therapeutic effect. Therefore, it is imperative to develop a versatile joint wound dressing that integrates adequate stretchability, desirable biocompatibility, and multiple biological effects into one system. We implemented the electrospinning technique in this study to fabricate a novel nanofibrous membrane (NFM) composed of gelatin (GEL) and astragalus polysaccharides (APS), termed GEL/APS NFM. The selection of GEL and APS confers excellent biocompatibility to GEL/APS NFM. Furthermore, the optimally proportioned GEL/APS NFM exhibits satisfactory stretchability and desirable wound healing efficiency. Furthermore, released APS can exert anti-inflammatory, procollagen deposition, and proangiogenic effects to accelerate epithelial tissue, enhancing joint wound healing. In summary, GEL/APS NFM offers a convenient and effective approach to promoting rapid joint wound healing, providing a novel approach to joint wound care.

KW - Anti-inflammatory

KW - Collagen deposition

KW - Electrospinning

KW - Joint wound management

KW - Nanofibrous membranes

UR - https://www.scopus.com/pages/publications/85165312832

U2 - 10.1016/j.ijbiomac.2023.125557

DO - 10.1016/j.ijbiomac.2023.125557

M3 - 文章

C2 - 37364811

AN - SCOPUS:85165312832

SN - 0141-8130

VL - 248

JO - International Journal of Biological Macromolecules

JF - International Journal of Biological Macromolecules

M1 - 125557

ER -

Astragalus polysaccharides driven stretchable nanofibrous membrane wound dressing for joint wound healing

Abstract

Keywords

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