Association of school residential PM2.5 with childhood high blood pressure: Results from an observational study in 6 cities in China

Xijie Wang; Zhiyong Zou; Bin Dong; Yanhui Dong; Yinghua Ma; Di Gao; Zhaogeng Yang; Shaowei Wu; Jun Ma

doi:10.3390/ijerph16142515

Association of school residential PM_2.5 with childhood high blood pressure: Results from an observational study in 6 cities in China

Xijie Wang
, Zhiyong Zou
, Bin Dong
, Yanhui Dong
, Yinghua Ma
, Di Gao
, Zhaogeng Yang
, Shaowei Wu
, Jun Ma

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Objective: To investigate the association of long-term PM_2.5 exposure with blood pressure (BP) outcomes in children aged 6–18 years, and to examine the population attributable risk (PAR) of PM_2.5 exposure. Methods: A total of 53,289 participants aged 6–18 years with full record of age, sex, BP, height, and local PM_2.5 exposure from a cross-sectional survey conducted in 6 cities of China in 2013 were involved in the present study. PM_2.5 data from 18 January 2013 to 31 December 2013 were obtained from the nearest environmental monitoring station for each selected school. Two-level linear and logistic regression models were used to evaluate the influence of PM_2.5 on children’s BP, and PAR was calculated in each sex and age group. Results: Participants had a mean age of 10.8 (standard deviation: 3.4) years at enrollment, 51.7% of them were boys. U-shaped trends along with increased PM_2.5 concentration were found for both systolic blood pressure (SBP) and diastolic blood pressure (DBP), with the thresholds of 57.8 and 65.0 μg/m³, respectively. Both increased annual mean of PM_2.5 concentration and ratio of polluted days were associated with increased BP levels and high blood pressure (HBP), with effect estimates for BP ranging from 2.80 (95% CI: −0.51, 6.11) mmHg to 5.78 (95% CI: 2.32, 9.25) mmHg for SBP and from 0.77 (95% CI: −1.98, 3.52) mmHg to 2.66 (−0.35, 5.66) mmHg for DBP, and the odds ratios for HBP from 1.21 (0.43, 3.38) to 1.92 (0.65, 5.67) in the highest vs. the lowest quartiles. Overall, 1.16% of HBP in our participants could be attributed to increased annual mean of PM_2.5 concentration, while 2.82% could be attributed to increased ratio of polluted days. These proportions increased with age. Conclusions: The association between long-term PM_2.5 exposure and BP values appeared to be U-shaped in Chinese children aged 6–18 years, and increased PM_2.5 exposure was associated with higher risk of HBP.

Original language	English
Article number	2515
Journal	International Journal of Environmental Research and Public Health
Volume	16
Issue number	14
DOIs	https://doi.org/10.3390/ijerph16142515
State	Published - 2 Jul 2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Air pollution
Children
High blood pressure
Particulate matter

Access to Document

10.3390/ijerph16142515

Cite this

@article{885a79a1f6874a8e935de40345979554,

title = "Association of school residential PM2.5 with childhood high blood pressure: Results from an observational study in 6 cities in China",

abstract = "Objective: To investigate the association of long-term PM2.5 exposure with blood pressure (BP) outcomes in children aged 6–18 years, and to examine the population attributable risk (PAR) of PM2.5 exposure. Methods: A total of 53,289 participants aged 6–18 years with full record of age, sex, BP, height, and local PM2.5 exposure from a cross-sectional survey conducted in 6 cities of China in 2013 were involved in the present study. PM2.5 data from 18 January 2013 to 31 December 2013 were obtained from the nearest environmental monitoring station for each selected school. Two-level linear and logistic regression models were used to evaluate the influence of PM2.5 on children{\textquoteright}s BP, and PAR was calculated in each sex and age group. Results: Participants had a mean age of 10.8 (standard deviation: 3.4) years at enrollment, 51.7\% of them were boys. U-shaped trends along with increased PM2.5 concentration were found for both systolic blood pressure (SBP) and diastolic blood pressure (DBP), with the thresholds of 57.8 and 65.0 μg/m3, respectively. Both increased annual mean of PM2.5 concentration and ratio of polluted days were associated with increased BP levels and high blood pressure (HBP), with effect estimates for BP ranging from 2.80 (95\% CI: −0.51, 6.11) mmHg to 5.78 (95\% CI: 2.32, 9.25) mmHg for SBP and from 0.77 (95\% CI: −1.98, 3.52) mmHg to 2.66 (−0.35, 5.66) mmHg for DBP, and the odds ratios for HBP from 1.21 (0.43, 3.38) to 1.92 (0.65, 5.67) in the highest vs. the lowest quartiles. Overall, 1.16\% of HBP in our participants could be attributed to increased annual mean of PM2.5 concentration, while 2.82\% could be attributed to increased ratio of polluted days. These proportions increased with age. Conclusions: The association between long-term PM2.5 exposure and BP values appeared to be U-shaped in Chinese children aged 6–18 years, and increased PM2.5 exposure was associated with higher risk of HBP.",

keywords = "Air pollution, Children, High blood pressure, Particulate matter",

author = "Xijie Wang and Zhiyong Zou and Bin Dong and Yanhui Dong and Yinghua Ma and Di Gao and Zhaogeng Yang and Shaowei Wu and Jun Ma",

note = "Publisher Copyright: {\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2019",

month = jul,

day = "2",

doi = "10.3390/ijerph16142515",

language = "英语",

volume = "16",

journal = "International Journal of Environmental Research and Public Health",

issn = "1661-7827",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "14",

}

TY - JOUR

T1 - Association of school residential PM2.5 with childhood high blood pressure

T2 - Results from an observational study in 6 cities in China

AU - Wang, Xijie

AU - Zou, Zhiyong

AU - Dong, Bin

AU - Dong, Yanhui

AU - Ma, Yinghua

AU - Gao, Di

AU - Yang, Zhaogeng

AU - Wu, Shaowei

AU - Ma, Jun

PY - 2019/7/2

Y1 - 2019/7/2

N2 - Objective: To investigate the association of long-term PM2.5 exposure with blood pressure (BP) outcomes in children aged 6–18 years, and to examine the population attributable risk (PAR) of PM2.5 exposure. Methods: A total of 53,289 participants aged 6–18 years with full record of age, sex, BP, height, and local PM2.5 exposure from a cross-sectional survey conducted in 6 cities of China in 2013 were involved in the present study. PM2.5 data from 18 January 2013 to 31 December 2013 were obtained from the nearest environmental monitoring station for each selected school. Two-level linear and logistic regression models were used to evaluate the influence of PM2.5 on children’s BP, and PAR was calculated in each sex and age group. Results: Participants had a mean age of 10.8 (standard deviation: 3.4) years at enrollment, 51.7% of them were boys. U-shaped trends along with increased PM2.5 concentration were found for both systolic blood pressure (SBP) and diastolic blood pressure (DBP), with the thresholds of 57.8 and 65.0 μg/m3, respectively. Both increased annual mean of PM2.5 concentration and ratio of polluted days were associated with increased BP levels and high blood pressure (HBP), with effect estimates for BP ranging from 2.80 (95% CI: −0.51, 6.11) mmHg to 5.78 (95% CI: 2.32, 9.25) mmHg for SBP and from 0.77 (95% CI: −1.98, 3.52) mmHg to 2.66 (−0.35, 5.66) mmHg for DBP, and the odds ratios for HBP from 1.21 (0.43, 3.38) to 1.92 (0.65, 5.67) in the highest vs. the lowest quartiles. Overall, 1.16% of HBP in our participants could be attributed to increased annual mean of PM2.5 concentration, while 2.82% could be attributed to increased ratio of polluted days. These proportions increased with age. Conclusions: The association between long-term PM2.5 exposure and BP values appeared to be U-shaped in Chinese children aged 6–18 years, and increased PM2.5 exposure was associated with higher risk of HBP.

AB - Objective: To investigate the association of long-term PM2.5 exposure with blood pressure (BP) outcomes in children aged 6–18 years, and to examine the population attributable risk (PAR) of PM2.5 exposure. Methods: A total of 53,289 participants aged 6–18 years with full record of age, sex, BP, height, and local PM2.5 exposure from a cross-sectional survey conducted in 6 cities of China in 2013 were involved in the present study. PM2.5 data from 18 January 2013 to 31 December 2013 were obtained from the nearest environmental monitoring station for each selected school. Two-level linear and logistic regression models were used to evaluate the influence of PM2.5 on children’s BP, and PAR was calculated in each sex and age group. Results: Participants had a mean age of 10.8 (standard deviation: 3.4) years at enrollment, 51.7% of them were boys. U-shaped trends along with increased PM2.5 concentration were found for both systolic blood pressure (SBP) and diastolic blood pressure (DBP), with the thresholds of 57.8 and 65.0 μg/m3, respectively. Both increased annual mean of PM2.5 concentration and ratio of polluted days were associated with increased BP levels and high blood pressure (HBP), with effect estimates for BP ranging from 2.80 (95% CI: −0.51, 6.11) mmHg to 5.78 (95% CI: 2.32, 9.25) mmHg for SBP and from 0.77 (95% CI: −1.98, 3.52) mmHg to 2.66 (−0.35, 5.66) mmHg for DBP, and the odds ratios for HBP from 1.21 (0.43, 3.38) to 1.92 (0.65, 5.67) in the highest vs. the lowest quartiles. Overall, 1.16% of HBP in our participants could be attributed to increased annual mean of PM2.5 concentration, while 2.82% could be attributed to increased ratio of polluted days. These proportions increased with age. Conclusions: The association between long-term PM2.5 exposure and BP values appeared to be U-shaped in Chinese children aged 6–18 years, and increased PM2.5 exposure was associated with higher risk of HBP.

KW - Air pollution

KW - Children

KW - High blood pressure

KW - Particulate matter

UR - https://www.scopus.com/pages/publications/85070463221

U2 - 10.3390/ijerph16142515

DO - 10.3390/ijerph16142515

M3 - 文章

C2 - 31337125

AN - SCOPUS:85070463221

SN - 1661-7827

VL - 16

JO - International Journal of Environmental Research and Public Health

JF - International Journal of Environmental Research and Public Health

IS - 14

M1 - 2515

ER -