Association of MICA gene polymorphisms with thionamide-induced agranulocytosis

P. Ma; P. Chen; J. Gao; H. Guo; S. Li; J. Yang; J. Lai; X. Yang; B. Zhang; Y. He

doi:10.1007/s40618-020-01319-0

Association of MICA gene polymorphisms with thionamide-induced agranulocytosis

P. Ma
, P. Chen
, J. Gao
, H. Guo
, S. Li
, J. Yang
, J. Lai
, X. Yang
, B. Zhang
, Y. He

Health Science Center

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Background: Thionamide-induced agranulocytosis (TIA), namely antithyroid drug (ATD)-induced agranulocytosis, is one of the most feared adverse effect of ATDs. It is defined as a granulocyte count of less than 0.5 × 10⁹/L after ATD administration. Several studies reported that TIA is associated with human leukocyte antigen (HLA) and nearby genes. Our previous study found that the susceptibility genes of TIA are similar in north China and European populations. Methods: We evaluated the associations of 23 candidate single nucleotide polymorphisms (SNPs) in 37 patients with TIA and 254 patients with Graves’ disease (GD) as controls by iPLEX MassARRAY system. Results: Five SNPs in the MHC class I polypeptide-related sequence A(MICA) genes [rs4349859 (p = 1.43E-7); rs145575084 (p = 5.79E-6); rs116135464 (p = 3.70E-5); rs148015908 (p = 3.79E-5) and rs189600525 (p = 2.15E-4)] were found to be significantly associated with TIA after Bonferroni correction. After combining with previous data of rs4349859 and HLA-B*27:05, the haplotype analysis showed that patients carrying P-A-C-A-T-T-A haplotype have a higher risk of TIA (p = 9.76E-7; OR = 14.85, 95% CI 3.63–60.77). Conclusion: Our findings suggest that five high linked SNPs of MICA gene are significantly associated with susceptibility to TIA.

Original language	English
Pages (from-to)	363-369
Number of pages	7
Journal	Journal of Endocrinological Investigation
Volume	44
Issue number	2
DOIs	https://doi.org/10.1007/s40618-020-01319-0
State	Published - Feb 2021

Keywords

Association
Graves’ disease
MICA
Thionamide-induced agranulocytosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s40618-020-01319-0

Cite this

@article{1bac6df797494cb7a9aab296622c6a01,

title = "Association of MICA gene polymorphisms with thionamide-induced agranulocytosis",

abstract = "Background: Thionamide-induced agranulocytosis (TIA), namely antithyroid drug (ATD)-induced agranulocytosis, is one of the most feared adverse effect of ATDs. It is defined as a granulocyte count of less than 0.5 × 109/L after ATD administration. Several studies reported that TIA is associated with human leukocyte antigen (HLA) and nearby genes. Our previous study found that the susceptibility genes of TIA are similar in north China and European populations. Methods: We evaluated the associations of 23 candidate single nucleotide polymorphisms (SNPs) in 37 patients with TIA and 254 patients with Graves{\textquoteright} disease (GD) as controls by iPLEX MassARRAY system. Results: Five SNPs in the MHC class I polypeptide-related sequence A(MICA) genes [rs4349859 (p = 1.43E-7); rs145575084 (p = 5.79E-6); rs116135464 (p = 3.70E-5); rs148015908 (p = 3.79E-5) and rs189600525 (p = 2.15E-4)] were found to be significantly associated with TIA after Bonferroni correction. After combining with previous data of rs4349859 and HLA-B*27:05, the haplotype analysis showed that patients carrying P-A-C-A-T-T-A haplotype have a higher risk of TIA (p = 9.76E-7; OR = 14.85, 95\% CI 3.63–60.77). Conclusion: Our findings suggest that five high linked SNPs of MICA gene are significantly associated with susceptibility to TIA.",

keywords = "Association, Graves{\textquoteright} disease, MICA, Thionamide-induced agranulocytosis",

author = "P. Ma and P. Chen and J. Gao and H. Guo and S. Li and J. Yang and J. Lai and X. Yang and B. Zhang and Y. He",

note = "Publisher Copyright: {\textcopyright} 2020, Italian Society of Endocrinology (SIE).",

year = "2021",

month = feb,

doi = "10.1007/s40618-020-01319-0",

language = "英语",

volume = "44",

pages = "363--369",

journal = "Journal of Endocrinological Investigation",

issn = "0391-4097",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "2",

}

TY - JOUR

T1 - Association of MICA gene polymorphisms with thionamide-induced agranulocytosis

AU - Ma, P.

AU - Chen, P.

AU - Gao, J.

AU - Guo, H.

AU - Li, S.

AU - Yang, J.

AU - Lai, J.

AU - Yang, X.

AU - Zhang, B.

AU - He, Y.

PY - 2021/2

Y1 - 2021/2

N2 - Background: Thionamide-induced agranulocytosis (TIA), namely antithyroid drug (ATD)-induced agranulocytosis, is one of the most feared adverse effect of ATDs. It is defined as a granulocyte count of less than 0.5 × 109/L after ATD administration. Several studies reported that TIA is associated with human leukocyte antigen (HLA) and nearby genes. Our previous study found that the susceptibility genes of TIA are similar in north China and European populations. Methods: We evaluated the associations of 23 candidate single nucleotide polymorphisms (SNPs) in 37 patients with TIA and 254 patients with Graves’ disease (GD) as controls by iPLEX MassARRAY system. Results: Five SNPs in the MHC class I polypeptide-related sequence A(MICA) genes [rs4349859 (p = 1.43E-7); rs145575084 (p = 5.79E-6); rs116135464 (p = 3.70E-5); rs148015908 (p = 3.79E-5) and rs189600525 (p = 2.15E-4)] were found to be significantly associated with TIA after Bonferroni correction. After combining with previous data of rs4349859 and HLA-B*27:05, the haplotype analysis showed that patients carrying P-A-C-A-T-T-A haplotype have a higher risk of TIA (p = 9.76E-7; OR = 14.85, 95% CI 3.63–60.77). Conclusion: Our findings suggest that five high linked SNPs of MICA gene are significantly associated with susceptibility to TIA.

AB - Background: Thionamide-induced agranulocytosis (TIA), namely antithyroid drug (ATD)-induced agranulocytosis, is one of the most feared adverse effect of ATDs. It is defined as a granulocyte count of less than 0.5 × 109/L after ATD administration. Several studies reported that TIA is associated with human leukocyte antigen (HLA) and nearby genes. Our previous study found that the susceptibility genes of TIA are similar in north China and European populations. Methods: We evaluated the associations of 23 candidate single nucleotide polymorphisms (SNPs) in 37 patients with TIA and 254 patients with Graves’ disease (GD) as controls by iPLEX MassARRAY system. Results: Five SNPs in the MHC class I polypeptide-related sequence A(MICA) genes [rs4349859 (p = 1.43E-7); rs145575084 (p = 5.79E-6); rs116135464 (p = 3.70E-5); rs148015908 (p = 3.79E-5) and rs189600525 (p = 2.15E-4)] were found to be significantly associated with TIA after Bonferroni correction. After combining with previous data of rs4349859 and HLA-B*27:05, the haplotype analysis showed that patients carrying P-A-C-A-T-T-A haplotype have a higher risk of TIA (p = 9.76E-7; OR = 14.85, 95% CI 3.63–60.77). Conclusion: Our findings suggest that five high linked SNPs of MICA gene are significantly associated with susceptibility to TIA.

KW - Association

KW - Graves’ disease

KW - MICA

KW - Thionamide-induced agranulocytosis

UR - https://www.scopus.com/pages/publications/85086245817

U2 - 10.1007/s40618-020-01319-0

DO - 10.1007/s40618-020-01319-0

M3 - 文章

C2 - 32519199

AN - SCOPUS:85086245817

SN - 0391-4097

VL - 44

SP - 363

EP - 369

JO - Journal of Endocrinological Investigation

JF - Journal of Endocrinological Investigation

IS - 2

ER -

Association of MICA gene polymorphisms with thionamide-induced agranulocytosis

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this