TY - JOUR
T1 - Association of genetic polymorphisms in MIF with breast cancer risk in Chinese women
AU - Lin, Shuai
AU - Wang, Meng
AU - Liu, Xinghan
AU - Zhu, Wenge
AU - Guo, Yan
AU - Dai, Zhiming
AU - Yang, Pengtao
AU - Tian, Tian
AU - Dai, Cong
AU - Zheng, Yi
AU - Hu, Chunyan
AU - Wei, Linyan
AU - Dai, Zhijun
N1 - Publisher Copyright:
© 2016, Springer International Publishing Switzerland.
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Macrophage migration inhibitory factor (MIF) has been reported to associate with increased cancer risk in several cancers. However, the role of MIF in breast cancer (BC) susceptibility remains unknown. For the first time, we conducted a case–control study to assess the potential association of three common MIF gene variants (rs755622, rs1803976, rs11548059) with BC susceptibility in Chinese women. Total 560 breast cancer patients and 583 age- and sex-matched healthy individuals were recruited from Northwest China, and the DNA was genotyped by Sequenom MassARRAY. Odds ratios (OR) and 95% confidence intervals (95% CI) were computed to estimate the associations. We found that C/G, C/C, and C/G–C/C genotype carriers in MIF rs755622 have a significantly increased risk of BC (C/G vs. G/G: OR = 1.36, 95% CI = 1.07–1.75, P = 0.014; C/C vs. GG: OR = 2.01, 95% CI = 1.06–3.79, P = 0.029; C/G–C/C vs. G/G: OR = 1.42 95% CI = 1.11–1.80, P = 0.004). Further analyses indicate that the BC risk is associated with Ki-67 status, and the rs755622 polymorphism increases breast cancer risk among elder patients (≥49 years). There is no association between BC risk and other two polymorphisms (rs1803976 and rs11548059) by overall analysis and stratified analysis. In conclusion, MIF rs755622 polymorphism increases BC susceptibility in Chinese population, especially among elder patients.
AB - Macrophage migration inhibitory factor (MIF) has been reported to associate with increased cancer risk in several cancers. However, the role of MIF in breast cancer (BC) susceptibility remains unknown. For the first time, we conducted a case–control study to assess the potential association of three common MIF gene variants (rs755622, rs1803976, rs11548059) with BC susceptibility in Chinese women. Total 560 breast cancer patients and 583 age- and sex-matched healthy individuals were recruited from Northwest China, and the DNA was genotyped by Sequenom MassARRAY. Odds ratios (OR) and 95% confidence intervals (95% CI) were computed to estimate the associations. We found that C/G, C/C, and C/G–C/C genotype carriers in MIF rs755622 have a significantly increased risk of BC (C/G vs. G/G: OR = 1.36, 95% CI = 1.07–1.75, P = 0.014; C/C vs. GG: OR = 2.01, 95% CI = 1.06–3.79, P = 0.029; C/G–C/C vs. G/G: OR = 1.42 95% CI = 1.11–1.80, P = 0.004). Further analyses indicate that the BC risk is associated with Ki-67 status, and the rs755622 polymorphism increases breast cancer risk among elder patients (≥49 years). There is no association between BC risk and other two polymorphisms (rs1803976 and rs11548059) by overall analysis and stratified analysis. In conclusion, MIF rs755622 polymorphism increases BC susceptibility in Chinese population, especially among elder patients.
KW - Breast cancer
KW - Gene variant
KW - MIF
KW - Susceptibility
UR - https://www.scopus.com/pages/publications/84995469489
U2 - 10.1007/s10238-016-0439-9
DO - 10.1007/s10238-016-0439-9
M3 - 文章
C2 - 27844180
AN - SCOPUS:84995469489
SN - 1591-8890
VL - 17
SP - 395
EP - 401
JO - Clinical and Experimental Medicine
JF - Clinical and Experimental Medicine
IS - 3
ER -
