Association of Fcgamma receptor type 2A and 3A genotypes with rheumatoid arthritis in Chinese population

Yining Sun; Lingfei Mo; Xiuyuan Feng; Dongmei Yang; Taochao Tan; Lingxia Zeng; Lingyun Hui; Yawen Wang; Cheng Liu; Lan He

doi:10.2217/pgs-2016-0159

Association of Fcgamma receptor type 2A and 3A genotypes with rheumatoid arthritis in Chinese population

Yining Sun
, Lingfei Mo
, Xiuyuan Feng
, Dongmei Yang
, Taochao Tan
, Lingxia Zeng
, Lingyun Hui
, Yawen Wang
, Cheng Liu
, Lan He

Health Science Center

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Aim: SNPs of FcγRs were implicated in pathogenesis of rheumatoid arthritis (RA) and treatment efficacy of TNF inhibitors (TNFi). This study aims to investigate the associations of FcγRIIa and FcγRIIIa genotypes with autoantibody production and treatment response to TNFi in Chinese patients with RA. Patients & methods: FcγRIIa and FcγRIIIa polymorphisms were genotyped in 158 RA patients. Response to TNFi was evaluated in 18 patients at 3 and 6 months after treatment. Results: FcγRIIa-131H allele was significantly increased in autoantibody-negative RA patients. FcγRIIa-131H/H+H/R was closely associated with differences in 28-joint disease activity score in patients at months 3 and 6 of TNFi treatment. Conclusion: FcγRIIa-131H allele may have a protective role in autoantibody production and might be a biomarker for predicting good response to TNFi in Chinese RA patients.

Original language	English
Pages (from-to)	255-264
Number of pages	10
Journal	Pharmacogenomics
Volume	18
Issue number	3
DOIs	https://doi.org/10.2217/pgs-2016-0159
State	Published - Feb 2017

Keywords

Fcgamma receptor
TNF inhibitors
anti-citrullinated protein antibody
polymorphisms
rheumatoid arthritis
rheumatoid factor

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@article{6881c4db4a064af6acca7a2c1caefd3f,

title = "Association of Fcgamma receptor type 2A and 3A genotypes with rheumatoid arthritis in Chinese population",

abstract = "Aim: SNPs of FcγRs were implicated in pathogenesis of rheumatoid arthritis (RA) and treatment efficacy of TNF inhibitors (TNFi). This study aims to investigate the associations of FcγRIIa and FcγRIIIa genotypes with autoantibody production and treatment response to TNFi in Chinese patients with RA. Patients \& methods: FcγRIIa and FcγRIIIa polymorphisms were genotyped in 158 RA patients. Response to TNFi was evaluated in 18 patients at 3 and 6 months after treatment. Results: FcγRIIa-131H allele was significantly increased in autoantibody-negative RA patients. FcγRIIa-131H/H+H/R was closely associated with differences in 28-joint disease activity score in patients at months 3 and 6 of TNFi treatment. Conclusion: FcγRIIa-131H allele may have a protective role in autoantibody production and might be a biomarker for predicting good response to TNFi in Chinese RA patients.",

keywords = "Fcgamma receptor, TNF inhibitors, anti-citrullinated protein antibody, polymorphisms, rheumatoid arthritis, rheumatoid factor",

author = "Yining Sun and Lingfei Mo and Xiuyuan Feng and Dongmei Yang and Taochao Tan and Lingxia Zeng and Lingyun Hui and Yawen Wang and Cheng Liu and Lan He",

note = "Publisher Copyright: {\textcopyright} 2017 Future Medicine Ltd.",

year = "2017",

month = feb,

doi = "10.2217/pgs-2016-0159",

language = "英语",

volume = "18",

pages = "255--264",

journal = "Pharmacogenomics",

issn = "1462-2416",

publisher = "Taylor and Francis Ltd.",

number = "3",

}

TY - JOUR

T1 - Association of Fcgamma receptor type 2A and 3A genotypes with rheumatoid arthritis in Chinese population

AU - Sun, Yining

AU - Mo, Lingfei

AU - Feng, Xiuyuan

AU - Yang, Dongmei

AU - Tan, Taochao

AU - Zeng, Lingxia

AU - Hui, Lingyun

AU - Wang, Yawen

AU - Liu, Cheng

AU - He, Lan

PY - 2017/2

Y1 - 2017/2

N2 - Aim: SNPs of FcγRs were implicated in pathogenesis of rheumatoid arthritis (RA) and treatment efficacy of TNF inhibitors (TNFi). This study aims to investigate the associations of FcγRIIa and FcγRIIIa genotypes with autoantibody production and treatment response to TNFi in Chinese patients with RA. Patients & methods: FcγRIIa and FcγRIIIa polymorphisms were genotyped in 158 RA patients. Response to TNFi was evaluated in 18 patients at 3 and 6 months after treatment. Results: FcγRIIa-131H allele was significantly increased in autoantibody-negative RA patients. FcγRIIa-131H/H+H/R was closely associated with differences in 28-joint disease activity score in patients at months 3 and 6 of TNFi treatment. Conclusion: FcγRIIa-131H allele may have a protective role in autoantibody production and might be a biomarker for predicting good response to TNFi in Chinese RA patients.

AB - Aim: SNPs of FcγRs were implicated in pathogenesis of rheumatoid arthritis (RA) and treatment efficacy of TNF inhibitors (TNFi). This study aims to investigate the associations of FcγRIIa and FcγRIIIa genotypes with autoantibody production and treatment response to TNFi in Chinese patients with RA. Patients & methods: FcγRIIa and FcγRIIIa polymorphisms were genotyped in 158 RA patients. Response to TNFi was evaluated in 18 patients at 3 and 6 months after treatment. Results: FcγRIIa-131H allele was significantly increased in autoantibody-negative RA patients. FcγRIIa-131H/H+H/R was closely associated with differences in 28-joint disease activity score in patients at months 3 and 6 of TNFi treatment. Conclusion: FcγRIIa-131H allele may have a protective role in autoantibody production and might be a biomarker for predicting good response to TNFi in Chinese RA patients.

KW - Fcgamma receptor

KW - TNF inhibitors

KW - anti-citrullinated protein antibody

KW - polymorphisms

KW - rheumatoid arthritis

KW - rheumatoid factor

UR - https://www.scopus.com/pages/publications/85011072530

U2 - 10.2217/pgs-2016-0159

DO - 10.2217/pgs-2016-0159

M3 - 文章

C2 - 28112584

AN - SCOPUS:85011072530

SN - 1462-2416

VL - 18

SP - 255

EP - 264

JO - Pharmacogenomics

JF - Pharmacogenomics

IS - 3

ER -

Association of Fcgamma receptor type 2A and 3A genotypes with rheumatoid arthritis in Chinese population

Abstract

Keywords

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