TY - JOUR
T1 - Association of exposure to fine particulate matter wave over the preconception and pregnancy periods with adverse birth outcomes
T2 - Results from the project ELEFANT
AU - Chen, Juan
AU - Wu, Shaowei
AU - Fang, Junkai
AU - Liu, Ziquan
AU - Shang, Xuejun
AU - Guo, Xinbiao
AU - Deng, Furong
AU - Guo, Liqiong
N1 - Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2022/4/1
Y1 - 2022/4/1
N2 - Background: No study has explored the effects of sustained maternal exposure to high-level ambient fine particulate matter (PM2.5) within a short period, i.e., PM2.5 wave, on adverse birth outcomes, though increasing epidemiological studies demonstrated that exposure to single days of high ambient PM2.5 could increase risks of adverse birth outcomes. In this study, we aim to evaluate associations of maternal PM2.5 wave exposure around pregnancy with preterm birth (PTB), small for gestational age (SGA), and large for gestational age (LGA). Methods: Totally 10,916 singleton pregnant women from all 16 districts in Tianjin, China, and their followed-up birth outcomes were included in this study. We defined PM2.5 wave as at least 2 consecutive days with daily average PM2.5 concentration exceeding 75 μg/m3, and 90th, 92.5th, 95th, 97.5th, 99th percentiles of PM2.5 distribution during the study period in Tianjin, respectively. Cox proportional hazard model was applied to evaluate the durational effects of PM2.5 wave during each exposure window on PTB, SGA, and LGA after adjusting for potential confounders. Results: Exposure to PM2.5 wave over the preconception and pregnancy periods was associated with increased risks of adverse birth outcomes. For PTB, the strongest association was found during the first trimester when PM2.5 wave was defined as at least 4 consecutive days with daily average PM2.5 concentration >90th (HR, 10.46; 95% CI, 6.23–17.54); and for SGA (HR, 6.23; 95% CI, 3.34–11.64) and LGA (HR, 4.70; 95% CI, 3.35–6.59), the strongest associations both were found when PM2.5 wave was defined as at least 2 consecutive days with daily average PM2.5 concentration >99th. Additionally, the risks of adverse birth outcomes generally increased at higher PM2.5 thresholds or longer durations of PM2.5 wave. Conclusion: Prolonged exposure to high-level PM2.5 over preconception and pregnancy periods was associated with increasing risks of PTB, SGA and LGA.
AB - Background: No study has explored the effects of sustained maternal exposure to high-level ambient fine particulate matter (PM2.5) within a short period, i.e., PM2.5 wave, on adverse birth outcomes, though increasing epidemiological studies demonstrated that exposure to single days of high ambient PM2.5 could increase risks of adverse birth outcomes. In this study, we aim to evaluate associations of maternal PM2.5 wave exposure around pregnancy with preterm birth (PTB), small for gestational age (SGA), and large for gestational age (LGA). Methods: Totally 10,916 singleton pregnant women from all 16 districts in Tianjin, China, and their followed-up birth outcomes were included in this study. We defined PM2.5 wave as at least 2 consecutive days with daily average PM2.5 concentration exceeding 75 μg/m3, and 90th, 92.5th, 95th, 97.5th, 99th percentiles of PM2.5 distribution during the study period in Tianjin, respectively. Cox proportional hazard model was applied to evaluate the durational effects of PM2.5 wave during each exposure window on PTB, SGA, and LGA after adjusting for potential confounders. Results: Exposure to PM2.5 wave over the preconception and pregnancy periods was associated with increased risks of adverse birth outcomes. For PTB, the strongest association was found during the first trimester when PM2.5 wave was defined as at least 4 consecutive days with daily average PM2.5 concentration >90th (HR, 10.46; 95% CI, 6.23–17.54); and for SGA (HR, 6.23; 95% CI, 3.34–11.64) and LGA (HR, 4.70; 95% CI, 3.35–6.59), the strongest associations both were found when PM2.5 wave was defined as at least 2 consecutive days with daily average PM2.5 concentration >99th. Additionally, the risks of adverse birth outcomes generally increased at higher PM2.5 thresholds or longer durations of PM2.5 wave. Conclusion: Prolonged exposure to high-level PM2.5 over preconception and pregnancy periods was associated with increasing risks of PTB, SGA and LGA.
KW - Fine particulate matter
KW - Fine particulate matter wave
KW - Large for gestational age
KW - Preterm birth
KW - Small for gestational age
UR - https://www.scopus.com/pages/publications/85121100033
U2 - 10.1016/j.envres.2021.112473
DO - 10.1016/j.envres.2021.112473
M3 - 文章
C2 - 34863986
AN - SCOPUS:85121100033
SN - 0013-9351
VL - 205
JO - Environmental Research
JF - Environmental Research
M1 - 112473
ER -