TY - JOUR
T1 - Association between pro-inflammatory diet and abdominal pain
T2 - cross-sectional and case-control study from UK biobank and NHANES 2017–2020
AU - Li, Laifu
AU - Zhuang, Yan
AU - Ran, Yan
AU - Chen, Jiamiao
AU - Wang, Lianli
AU - Lu, Shiwei
AU - Sun, Yating
AU - Ye, Fangchen
AU - Dai, Fei
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/8/1
Y1 - 2024/8/1
N2 - Background: There is a close association between diet and abdominal pain; however, relationship between inflammatory diet and characteristics of abdominal pain has not been characterized yet. Methods: This study analyzed baseline data from the UK Biobank, 3-item DHQ-Abdominal Pain Questionnaire (DHQ-3Q), which including abdominal pain in the past 3 months, severity of abdominal pain, and frequency of abdominal pain, and data from the National Health and Nutrition Examination Survey (NHANES) from 2017 to 2020. Energy-adjusted Dietary Inflammatory Index (E-DII), constructed based on 26 or 27 nutrients, was analyzed using continuous or categorical methods. Logistic regression and restricted cubic spline analyses examined the association between E-DII and abdominal pain. Results: In UK Biobank, compared to participants in the lowest quintile of E-DII, the adjusted ORs for the highest quintile were 1.12 (95% CI 1.02–1.24; P ¼ .022), 1.05 (95% CI 1.00–1.09; P ¼ .030), 1.26 (95% CI 1.17–1.36; P < .001), and 1.10 (95% CI 1.00–1.20; P ¼ .044) for chronic abdominal pain, abdominal pain in the past three months, severity of abdominal pain, and frequency of abdominal pain, respectively. In NHANES, compared to participants in the lowest quintile of E-DII, the adjusted ORs for the highest quintile were 1.46 (95% CI 1.20–1.77; P < .001), 1.75 (95% CI 1.20–2.60; P ¼ .005), 1.45 (95% CI 1.14–1.87; P ¼ .003), and 1.18 (95% CI 0.82–1.72; P ¼ .380) for abdominal pain in the past year, upper left abdominal pain, upper middle abdominal pain, and upper right abdominal pain. Additionally, there was a nonlinear correlation between E-DII score and DHQ-3Q (P nonlinear < .001). Conclusion: Following a pro-inflammatory diet is linked to a higher likelihood of experiencing abdominal pain, as well as increased severity and frequency of such pain. Therefore, further longitudinal studies are necessary to investigate this relationship.
AB - Background: There is a close association between diet and abdominal pain; however, relationship between inflammatory diet and characteristics of abdominal pain has not been characterized yet. Methods: This study analyzed baseline data from the UK Biobank, 3-item DHQ-Abdominal Pain Questionnaire (DHQ-3Q), which including abdominal pain in the past 3 months, severity of abdominal pain, and frequency of abdominal pain, and data from the National Health and Nutrition Examination Survey (NHANES) from 2017 to 2020. Energy-adjusted Dietary Inflammatory Index (E-DII), constructed based on 26 or 27 nutrients, was analyzed using continuous or categorical methods. Logistic regression and restricted cubic spline analyses examined the association between E-DII and abdominal pain. Results: In UK Biobank, compared to participants in the lowest quintile of E-DII, the adjusted ORs for the highest quintile were 1.12 (95% CI 1.02–1.24; P ¼ .022), 1.05 (95% CI 1.00–1.09; P ¼ .030), 1.26 (95% CI 1.17–1.36; P < .001), and 1.10 (95% CI 1.00–1.20; P ¼ .044) for chronic abdominal pain, abdominal pain in the past three months, severity of abdominal pain, and frequency of abdominal pain, respectively. In NHANES, compared to participants in the lowest quintile of E-DII, the adjusted ORs for the highest quintile were 1.46 (95% CI 1.20–1.77; P < .001), 1.75 (95% CI 1.20–2.60; P ¼ .005), 1.45 (95% CI 1.14–1.87; P ¼ .003), and 1.18 (95% CI 0.82–1.72; P ¼ .380) for abdominal pain in the past year, upper left abdominal pain, upper middle abdominal pain, and upper right abdominal pain. Additionally, there was a nonlinear correlation between E-DII score and DHQ-3Q (P nonlinear < .001). Conclusion: Following a pro-inflammatory diet is linked to a higher likelihood of experiencing abdominal pain, as well as increased severity and frequency of such pain. Therefore, further longitudinal studies are necessary to investigate this relationship.
KW - Energy-adjusted Dietary Inflammatory Index
KW - UK Biobank, NHANES
KW - abdominal pain
KW - inflammatory diet
UR - https://www.scopus.com/pages/publications/85200270365
U2 - 10.1093/pm/pnae028
DO - 10.1093/pm/pnae028
M3 - 文章
C2 - 38652573
AN - SCOPUS:85200270365
SN - 1526-2375
VL - 25
SP - 523
EP - 533
JO - Pain Medicine (United States)
JF - Pain Medicine (United States)
IS - 8
ER -