Association between paraoxonase concentration and risk of acute coronary syndrome

Objective: To investigate the relationship between paraoxonase (PON) concentration and the risk of acute coronary syndrome (ACS). Methods: The levels of serum PON were detected by enzyme-linked immunosorbent assay in 229 patients with confirmed ACS and 129 control subjects without CHD. Logistic' regression analysis and receiver operating characteristic (ROC) curve analysis were applied to analyze the association between PON and ACS. Results: PON was significantly lower in ACS group than in control group [IgPON: (5.72±0.73) ng/L vs. (5.07±0.57) ng/L, P<0.05]. Logistic regression analysis showed that the level of PON was an independent risk factor of ACS (regression coeffient was -1.793 in univariate logistic regression, OR=0.166, 95% CI:0.088-0.316; -0.779 in multivariate logistic regression, OR=0.459, 95% CI:0.222-0.949). ROC analysis showed that the optimal diagnostic cut-off point of PON for ACS was 180 mg/L (sensitivity:83.3%, specificity:71.2%). Multiple stepwise regression analysis revealed that there was no significant correlation between IgPON and Gensini score in ACS patients. Conclusion: Lower PON is linked with increased risk of ACS, but does not relate with the severity of coronary stenosis.