Association between AHR in EGCs and IBS-D patients: the indole pathway of tryptophan metabolism

Lianli Wang; Yue Zhang; Yan Ran; Laifu Li; Lin Mei; Fangchen Ye; Yating Sun; Ting Wang; Xiaojing Quan; Haitao Shi; Fei Dai

doi:10.3389/fnut.2025.1566595

Association between AHR in EGCs and IBS-D patients: the indole pathway of tryptophan metabolism

Lianli Wang
, Yue Zhang
, Yan Ran
, Laifu Li
, Lin Mei
, Fangchen Ye
, Yating Sun
, Ting Wang
, Xiaojing Quan
, Haitao Shi
, Fei Dai

The Second Affiliated Hospital of Xi'an Jiaotong University
Xi'an Jiaotong University

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The pathophysiological mechanisms of irritable bowel syndrome (IBS) are related to the indole metabolic pathway of TRP. Our study is to emphasizes the association between AHR in EGC and intestinal function, and suggest that indole metabolites of TRP may have a protective effect on the gut by regulating AHR. (Figure presented.)

Original language	English
Article number	1566595
Journal	Frontiers in Nutrition
Volume	12
DOIs	https://doi.org/10.3389/fnut.2025.1566595
State	Published - 2025
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

IBS-D
aryl hydrocarbon receptor
enteric glial cells
inflammation
tryptophan

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10.3389/fnut.2025.1566595

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title = "Association between AHR in EGCs and IBS-D patients: the indole pathway of tryptophan metabolism",

abstract = "The pathophysiological mechanisms of irritable bowel syndrome (IBS) are related to the indole metabolic pathway of TRP. Our study is to emphasizes the association between AHR in EGC and intestinal function, and suggest that indole metabolites of TRP may have a protective effect on the gut by regulating AHR. (Figure presented.)",

keywords = "IBS-D, aryl hydrocarbon receptor, enteric glial cells, inflammation, tryptophan",

author = "Lianli Wang and Yue Zhang and Yan Ran and Laifu Li and Lin Mei and Fangchen Ye and Yating Sun and Ting Wang and Xiaojing Quan and Haitao Shi and Fei Dai",

note = "Publisher Copyright: Copyright {\textcopyright} 2025 Wang, Zhang, Ran, Li, Mei, Ye, Sun, Wang, Quan, Shi and Dai.",

year = "2025",

doi = "10.3389/fnut.2025.1566595",

language = "英语",

volume = "12",

journal = "Frontiers in Nutrition",

issn = "2296-861X",

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TY - JOUR

T1 - Association between AHR in EGCs and IBS-D patients

T2 - the indole pathway of tryptophan metabolism

AU - Wang, Lianli

AU - Zhang, Yue

AU - Ran, Yan

AU - Li, Laifu

AU - Mei, Lin

AU - Ye, Fangchen

AU - Sun, Yating

AU - Wang, Ting

AU - Quan, Xiaojing

AU - Shi, Haitao

AU - Dai, Fei

PY - 2025

Y1 - 2025

N2 - The pathophysiological mechanisms of irritable bowel syndrome (IBS) are related to the indole metabolic pathway of TRP. Our study is to emphasizes the association between AHR in EGC and intestinal function, and suggest that indole metabolites of TRP may have a protective effect on the gut by regulating AHR. (Figure presented.)

AB - The pathophysiological mechanisms of irritable bowel syndrome (IBS) are related to the indole metabolic pathway of TRP. Our study is to emphasizes the association between AHR in EGC and intestinal function, and suggest that indole metabolites of TRP may have a protective effect on the gut by regulating AHR. (Figure presented.)

KW - IBS-D

KW - aryl hydrocarbon receptor

KW - enteric glial cells

KW - inflammation

KW - tryptophan

UR - https://www.scopus.com/pages/publications/105002218110

U2 - 10.3389/fnut.2025.1566595

DO - 10.3389/fnut.2025.1566595

M3 - 文章

AN - SCOPUS:105002218110

SN - 2296-861X

VL - 12

JO - Frontiers in Nutrition

JF - Frontiers in Nutrition

M1 - 1566595

ER -

Association between AHR in EGCs and IBS-D patients: the indole pathway of tryptophan metabolism

Abstract

UN SDGs

Keywords

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