Antioxidant and antibacterial phytate hydrogel for MRSA infected wound healing

Xueyun Gong; Mi Chen; Bo Lei; Weidong Xia; Xingxing Zhang

doi:10.1016/j.matlet.2022.131690

Antioxidant and antibacterial phytate hydrogel for MRSA infected wound healing

Xueyun Gong
, Mi Chen
, Bo Lei
, Weidong Xia
, Xingxing Zhang

Frontier Institute of Science and Technology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) infected wound healing and repair is still a challenge. Herein, we developed an in situ-formed copper phytate nanoparticle-F127 hydrogel (FPSCu) with multifunctional properties for MRSA-infected wound treating. FPSCu hydrogel showed the injectability, temperature sensitivity, inherent antioxidant activity and high antibacterial activity against MRSA, as well as good biocompatibility. The MRSA infected wound model in mice showed that the FPSCu hydrogel could inhibit bacterial infection and accelerate wound healing. The facile preparation process and multifunctional bioactivities enable FPSCu the highly promising as the advanced dressing for wound repair.

Original language	English
Article number	131690
Journal	Materials Letters
Volume	312
DOIs	https://doi.org/10.1016/j.matlet.2022.131690
State	Published - 1 Apr 2022

Keywords

Biomaterials
Hydrogel
Nanocomposites
Wound healing

Access to Document

10.1016/j.matlet.2022.131690

Cite this

@article{2ae00e5b1bed4485bfd56e415045c751,

title = "Antioxidant and antibacterial phytate hydrogel for MRSA infected wound healing",

abstract = "Methicillin-resistant Staphylococcus aureus (MRSA) infected wound healing and repair is still a challenge. Herein, we developed an in situ-formed copper phytate nanoparticle-F127 hydrogel (FPSCu) with multifunctional properties for MRSA-infected wound treating. FPSCu hydrogel showed the injectability, temperature sensitivity, inherent antioxidant activity and high antibacterial activity against MRSA, as well as good biocompatibility. The MRSA infected wound model in mice showed that the FPSCu hydrogel could inhibit bacterial infection and accelerate wound healing. The facile preparation process and multifunctional bioactivities enable FPSCu the highly promising as the advanced dressing for wound repair.",

keywords = "Biomaterials, Hydrogel, Nanocomposites, Wound healing",

author = "Xueyun Gong and Mi Chen and Bo Lei and Weidong Xia and Xingxing Zhang",

note = "Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",

year = "2022",

month = apr,

day = "1",

doi = "10.1016/j.matlet.2022.131690",

language = "英语",

volume = "312",

journal = "Materials Letters",

issn = "0167-577X",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Antioxidant and antibacterial phytate hydrogel for MRSA infected wound healing

AU - Gong, Xueyun

AU - Chen, Mi

AU - Lei, Bo

AU - Xia, Weidong

AU - Zhang, Xingxing

PY - 2022/4/1

Y1 - 2022/4/1

N2 - Methicillin-resistant Staphylococcus aureus (MRSA) infected wound healing and repair is still a challenge. Herein, we developed an in situ-formed copper phytate nanoparticle-F127 hydrogel (FPSCu) with multifunctional properties for MRSA-infected wound treating. FPSCu hydrogel showed the injectability, temperature sensitivity, inherent antioxidant activity and high antibacterial activity against MRSA, as well as good biocompatibility. The MRSA infected wound model in mice showed that the FPSCu hydrogel could inhibit bacterial infection and accelerate wound healing. The facile preparation process and multifunctional bioactivities enable FPSCu the highly promising as the advanced dressing for wound repair.

AB - Methicillin-resistant Staphylococcus aureus (MRSA) infected wound healing and repair is still a challenge. Herein, we developed an in situ-formed copper phytate nanoparticle-F127 hydrogel (FPSCu) with multifunctional properties for MRSA-infected wound treating. FPSCu hydrogel showed the injectability, temperature sensitivity, inherent antioxidant activity and high antibacterial activity against MRSA, as well as good biocompatibility. The MRSA infected wound model in mice showed that the FPSCu hydrogel could inhibit bacterial infection and accelerate wound healing. The facile preparation process and multifunctional bioactivities enable FPSCu the highly promising as the advanced dressing for wound repair.

KW - Biomaterials

KW - Hydrogel

KW - Nanocomposites

KW - Wound healing

UR - https://www.scopus.com/pages/publications/85122734522

U2 - 10.1016/j.matlet.2022.131690

DO - 10.1016/j.matlet.2022.131690

M3 - 文章

AN - SCOPUS:85122734522

SN - 0167-577X

VL - 312

JO - Materials Letters

JF - Materials Letters

M1 - 131690

ER -

Antioxidant and antibacterial phytate hydrogel for MRSA infected wound healing

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this